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Tdark
INTS14
Integrator complex subunit 14

Protein Summary
Description
Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313182
  • ENSP00000326379
  • ENSG00000138614
  • ENST00000420799
  • ENSP00000408429
  • ENST00000431261
  • ENSP00000402898

Symbol
  • C15orf44
  • VWA9
  • VWA9
  • C15orf44
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.64   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 83   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.64   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (96)
INTS10
Tbio
Novelty:  0.15415606
p_int:  0.999788227
p_ni:  0.000211771
p_wrong:  2e-9
Score:  0.947
Data Source:  BioPlex,STRINGDB
BCL7C
Tdark
Novelty:  0.31203802
p_int:  0.97607206
p_ni:  0.023927905
p_wrong:  3.5e-8
Data Source:  BioPlex
TMEM87A
Tdark
Novelty:  0.33614983
p_int:  0.959827711
p_ni:  0.040172289
Data Source:  BioPlex
PPIAL4G
Tdark
Family:  Enzyme
Novelty:  0.93726521
p_int:  0.906325512
p_ni:  0.089227602
p_wrong:  0.004446886
Score:  0.169
Data Source:  BioPlex,STRINGDB
TRPC4AP
Tbio
Novelty:  0.02170224
p_int:  0.863449456
p_ni:  0.136457487
p_wrong:  0.000093057
Data Source:  BioPlex
TGM5
Tbio
Family:  Enzyme
Novelty:  0.01209333
p_int:  0.79982109
p_ni:  0.200178173
p_wrong:  7.37e-7
Score:  0.189
Data Source:  BioPlex,STRINGDB
LGALS7
Tbio
Novelty:  0.00753996
p_int:  0.796388702
p_ni:  0.203611297
p_wrong:  2e-9
Data Source:  BioPlex
IQCF1
Tdark
Novelty:  0.78525464
p_int:  0.788506077
p_ni:  0.211493922
p_wrong:  1e-9
Data Source:  BioPlex
INSL5
Tbio
Novelty:  0.04351334
p_int:  0.769426013
p_ni:  0.23057398
p_wrong:  7e-9
Data Source:  BioPlex
INTS3
Tbio
Novelty:  0.13398603
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
2
2
2
95.9
self reported educational attainment
3
3
2
6.4
88.1
mathematical ability
2
2
2
79.4
hemoglobin measurement
1
1
1
73.9
heel bone mineral density
2
1
2
64.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
2
95.9
self reported educational attainment
2
6.4
88.1
mathematical ability
2
79.4
hemoglobin measurement
1
73.9
heel bone mineral density
2
64.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
integrator complex subunit 14
VGNC:1581
453520
Macaque
integrator complex subunit 14
100426956
Mouse
MGI:1917132
69882
Rat
RGD:1359616
300782
Dog
integrator complex subunit 14
VGNC:42050
487606
Species
Name
OMA
EggNOG
Inparanoid
Chimp
integrator complex subunit 14
Macaque
integrator complex subunit 14
Mouse
Rat
Dog
integrator complex subunit 14
Publication Statistics
PubMed Score 0.64
PubMed score by year
PubTator Score 0.14
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title