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Tbio
INTS12
Integrator complex subunit 12

Protein Summary
Description
Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (PubMed:16239144). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267). INTS12 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340139
  • ENSP00000340737
  • ENSG00000138785
  • ENST00000394735
  • ENSP00000378221
  • ENST00000451321
  • ENSP00000415433

Symbol
  • PHF22
  • INT12
  • PHF22
  • SBBI22
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
gene perturbation
0.78
interacting protein
0.78
kinase perturbation
0.76
transcription factor binding site profile
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.94   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 72   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.94   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 72   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (126)
INTS1
Tbio
Novelty:  0.17523407
p_int:  0.999974777
p_ni:  0.000025222
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
ALDH3A2
Tbio
Family:  Enzyme
Novelty:  0.0059198
p_int:  0.984725542
p_ni:  0.015274284
p_wrong:  1.74e-7
Score:  0.206
Data Source:  BioPlex,STRINGDB
CTAG2
Tbio
Novelty:  0.02983879
p_int:  0.975280712
p_ni:  0.024719288
Data Source:  BioPlex
TAS2R7
Tchem
Family:  GPCR
Novelty:  0.10029148
p_int:  0.970163694
p_ni:  0.029834473
p_wrong:  0.000001834
Score:  0.181
Data Source:  BioPlex,STRINGDB
APLNR
Tchem
Family:  GPCR
Novelty:  0.00224203
p_int:  0.965481241
p_ni:  0.034518751
p_wrong:  8e-9
Data Source:  BioPlex
IL13RA2
Tbio
Novelty:  0.03465642
p_int:  0.963021948
p_ni:  0.03697804
p_wrong:  1.1e-8
Data Source:  BioPlex
EDNRB
Tclin
Family:  GPCR
Novelty:  0.00053875
p_int:  0.955659544
p_ni:  0.044337202
p_wrong:  0.000003254
Data Source:  BioPlex
SLC2A9
Tbio
Family:  Transporter
Novelty:  0.00683926
p_int:  0.953989674
p_ni:  0.046010324
p_wrong:  2e-9
Data Source:  BioPlex
ILVBL
Tbio
Family:  Enzyme
Novelty:  0.00297467
p_int:  0.921489698
p_ni:  0.078510151
p_wrong:  1.51e-7
Score:  0.313
Data Source:  BioPlex,STRINGDB
ARL13A
Tdark
Family:  Enzyme
Novelty:  0.19381742
p_int:  0.917251427
p_ni:  0.082746274
p_wrong:  0.000002299
Score:  0.19
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
RNA Polymerase II Transcription
Reactome
RNA polymerase II transcribes snRNA genes
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
RNA Polymerase II Transcription
RNA polymerase II transcribes snRNA genes
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
forced expiratory volume
7
5
6
1.2
98.6
FEV/FEC ratio
2
3
3
97.7
2
4
0
1.2
96.7
peak expiratory flow
1
2
2
93
vital capacity
2
2
3
90.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
forced expiratory volume
6
1.2
98.6
FEV/FEC ratio
3
97.7
0
1.2
96.7
peak expiratory flow
2
93
vital capacity
3
90.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
integrator complex subunit 12
VGNC:619
461418
Macaque
integrator complex subunit 12
694344
Mouse
MGI:1919043
71793
Rat
RGD:1359136
295448
Dog
integrator complex subunit 12
VGNC:42048
487889
Species
Name
OMA
EggNOG
Inparanoid
Chimp
integrator complex subunit 12
Macaque
integrator complex subunit 12
Mouse
Rat
Dog
integrator complex subunit 12
Publication Statistics
PubMed Score 12.94
PubMed score by year
PubTator Score 4.15
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title