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Tbio
INTS10
Integrator complex subunit 10

Protein Summary
Description
Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). May be not involved in the recruitment of cytoplasmic dynein to the nuclear envelope by different components of the INT complex (PubMed:23904267). INTS10 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000397977
  • ENSP00000381064
  • ENSG00000104613

Symbol
  • C8orf35
  • INT10
  • C8orf35
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.87
transcription factor binding site profile
0.83
tissue sample
0.67
tissue
0.65
cell type or tissue
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.5   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 188   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.5   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 188   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (115)
INTS13
Tbio
Novelty:  0.05454723
p_int:  1
Score:  0.964
Data Source:  BioPlex,STRINGDB
INTS14
Tdark
Novelty:  1.33783374
p_int:  0.999788227
p_ni:  0.000211771
p_wrong:  2e-9
Score:  0.947
Data Source:  BioPlex,STRINGDB
PGK2
Tbio
Family:  Kinase
Novelty:  0.00832045
p_int:  0.889274109
p_ni:  0.105104044
p_wrong:  0.005621847
Score:  0.188
Data Source:  BioPlex,STRINGDB
ACTBL2
Tbio
Novelty:  0.18080702
p_int:  0.8528334
p_ni:  0.1471666
Data Source:  BioPlex
INTS1
Tbio
Novelty:  0.17523407
Score:  0.999
Data Source:  STRINGDB
INTS3
Tbio
Novelty:  0.13398603
Score:  0.999
Data Source:  STRINGDB
INTS5
Tbio
Novelty:  0.02127142
Score:  0.999
Data Source:  STRINGDB
INTS6
Tbio
Novelty:  0.02680242
Score:  0.999
Data Source:  STRINGDB
INTS9
Tbio
Novelty:  0.06037786
Score:  0.992
Data Source:  STRINGDB
INTS12
Tbio
Family:  Epigenetic
Novelty:  0.09023473
Score:  0.991
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
RNA Polymerase II Transcription
Reactome
RNA polymerase II transcribes snRNA genes
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
RNA Polymerase II Transcription
RNA polymerase II transcribes snRNA genes
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
5
18
21
99.6
high density lipoprotein cholesterol measurement
6
17
19
5.5
99.6
apolipoprotein A 1 measurement
2
11
11
99.1
sleep duration
4
6
12
92.8
apolipoprotein B measurement
2
3
3
86.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
21
99.6
high density lipoprotein cholesterol measurement
19
5.5
99.6
apolipoprotein A 1 measurement
11
99.1
sleep duration
12
92.8
apolipoprotein B measurement
3
86.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
integrator complex subunit 10
705240
Mouse
MGI:1918135
70885
Rat
RGD:1304711
290679
Dog
integrator complex subunit 10
VGNC:42046
475565
Horse
integrator complex subunit 10
VGNC:19086
100053115
Species
Name
OMA
EggNOG
Inparanoid
Macaque
integrator complex subunit 10
Mouse
Rat
Dog
integrator complex subunit 10
Horse
integrator complex subunit 10
Publication Statistics
PubMed Score 7.50
PubMed score by year
PubTator Score 8.54
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title