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Tdark
INSYN2
Inhibitory synaptic factor 2A

Protein Summary
Description
Component of the protein machinery at the inhibitory synapses, probably acting as a scaffold. Inhibitory synapses dampen neuronal activity through postsynaptic hyperpolarization. This synaptic inhibition is fundamental for the functioning of the central nervous system, shaping and orchestrating the flow of information through neuronal networks to generate a precise neural code.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000424811
  • ENSP00000428730
  • ENSG00000188916
  • ENST00000522781
  • ENSP00000429763
  • ENST00000614311
  • ENSP00000479733

Symbol
  • C10orf141
  • FAM196A
  • INSYN2
  • FAM196A
  • C10orf141
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.64
microRNA
0.58
tissue
0.55
tissue sample
0.52
gene perturbation
0.44


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.18   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 8   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.18   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 8   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (54)
RUNDC1
Tdark
Novelty:  1.23644681
p_int:  0.999955019
p_ni:  0.000044884
p_wrong:  9.7e-8
Score:  0.175
Data Source:  BioPlex,STRINGDB
PRUNE1
Tchem
Novelty:  0.02136836
p_int:  0.999943881
p_ni:  0.000056119
Data Source:  BioPlex
EFL1
Tbio
Novelty:  0.1323879
p_int:  0.999852812
p_ni:  0.000089002
p_wrong:  0.000058186
Score:  0.189
Data Source:  BioPlex,STRINGDB
STX5
Tbio
Novelty:  0.00964918
p_int:  0.999795179
p_ni:  0.000204821
Data Source:  BioPlex
STAT2
Tbio
Family:  TF
Novelty:  0.00241454
p_int:  0.999780745
p_ni:  0.000219255
Data Source:  BioPlex
LRBA
Tbio
Novelty:  0.00093369
p_int:  0.998932603
p_ni:  0.001067211
p_wrong:  1.86e-7
Data Source:  BioPlex
IQSEC1
Tbio
Novelty:  0.05524352
p_int:  0.998404866
p_ni:  0.001595133
p_wrong:  1e-9
Score:  0.175
Data Source:  BioPlex,STRINGDB
USP4
Tchem
Family:  Enzyme
Novelty:  0.01101075
p_int:  0.998273037
p_ni:  0.001390521
p_wrong:  0.000336442
Data Source:  BioPlex
IKBKG
Tbio
Family:  Kinase
Novelty:  0.0006149
p_int:  0.998030021
p_ni:  0.001969957
p_wrong:  2.3e-8
Data Source:  BioPlex
CHUK
Tchem
Family:  Kinase
Novelty:  0.00151532
p_int:  0.997791425
p_ni:  0.002203829
p_wrong:  0.000004746
Score:  0.305
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
gut microbiome measurement
1
2
2
48
bone density
1
2
2
48
insulin resistance
1
1
0
9.2
43
educational attainment
1
1
1
25.8
high density lipoprotein cholesterol measurement
1
1
1
21.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
gut microbiome measurement
2
48
bone density
2
48
insulin resistance
0
9.2
43
educational attainment
1
25.8
high density lipoprotein cholesterol measurement
1
21.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 1.18
PubMed score by year
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Related Publications
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PMID
Year
Title