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Tdark
INSL6
Insulin-like peptide INSL6

Protein Summary
Description
May have a role in sperm development and fertilization. The protein encoded by this gene contains a classical signature of the insulin superfamily and is significantly similar to relaxin and relaxin-like factor. This gene is preferentially expressed in testis. Its expression in testis is restricted to interstitial cells surrounding seminiferous tubules, which suggests a role in sperm development and fertilization. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381641
  • ENSP00000371054
  • ENSG00000120210

Symbol
  • RIF1
  • RIF1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.55
cell line
0.51
gene perturbation
0.49
tissue sample
0.45
cell type or tissue
0.44


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.06   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 40   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.06   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 40   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (36)
TCEAL9
Tdark
Novelty:  0.3050647
p_int:  0.999984001
p_ni:  0.000007403
p_wrong:  0.000008596
Score:  0.672
Data Source:  BioPlex,STRINGDB
UBAC1
Tbio
Novelty:  0.00122518
p_int:  0.999458953
p_ni:  0.000541047
Data Source:  BioPlex
GID4
Tbio
Novelty:  0.05252674
p_int:  0.998158188
p_ni:  0.001841812
Data Source:  BioPlex
RNF123
Tbio
Family:  Enzyme
Novelty:  0.01872044
p_int:  0.997061259
p_ni:  0.002938741
Data Source:  BioPlex
WDR26
Tbio
Novelty:  0.04140166
p_int:  0.994312671
p_ni:  0.005687329
Score:  0.195
Data Source:  BioPlex,STRINGDB
ZMYND19
Tdark
Novelty:  0.3590069
p_int:  0.994245457
p_ni:  0.00575453
p_wrong:  1.3e-8
Data Source:  BioPlex
MKLN1
Tbio
Novelty:  0.05014385
p_int:  0.986460863
p_ni:  0.013539137
Data Source:  BioPlex
PPM1A
Tchem
Family:  Enzyme
Novelty:  0.01464968
p_int:  0.983149076
p_ni:  0.016850924
Data Source:  BioPlex
ACIN1
Tbio
Novelty:  0.01675479
p_int:  0.977370811
p_ni:  0.022629189
Data Source:  BioPlex
MAEA
Tbio
Novelty:  0.00833813
p_int:  0.977016146
p_ni:  0.022983854
Score:  0.169
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (2)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (26)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
4
7
9
49.9
99.2
platelet crit
2
5
7
98.9
3
3
0
2
97.7
eosinophil count
2
3
3
95.1
eosinophil percentage of leukocytes
2
3
3
93.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
9
49.9
99.2
platelet crit
7
98.9
0
2
97.7
eosinophil count
3
95.1
eosinophil percentage of leukocytes
3
93.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
insulin like 6
VGNC:4766
736778
Mouse
MGI:1351595
27356
Rat
RGD:62061
50546
Dog
insulin like 6
VGNC:42041
476343
Cow
insulin like 6
VGNC:30219
774023
Species
Name
OMA
EggNOG
Inparanoid
Chimp
insulin like 6
Mouse
Rat
Dog
insulin like 6
Cow
insulin like 6
Publication Statistics
PubMed Score 15.06
PubMed score by year
PubTator Score 12.78
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title