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Tbio
INS
Insulin

Protein Summary
Description
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2019]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000250971
  • ENSP00000250971
  • ENSG00000254647
  • ENST00000381330
  • ENSP00000370731
  • ENST00000397262
  • ENSP00000380432

Symbol
  • IDDM
  • ILPR
  • IRDN
  • IDDM1
  • IDDM2
  • MODY10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
1
phenotype
0.76
disease perturbation
0.74


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 226021.99   (req: < 5)
Gene RIFs: 666   (req: <= 3)
Antibodies: 3206   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 226021.99   (req: >= 5)
Gene RIFs: 666   (req: > 3)
Antibodies: 3206   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 68
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (1651)
UBR2
Tbio
Family:  Enzyme
Novelty:  0.03126228
p_int:  0.997933351
p_ni:  0.002066649
Data Source:  BioPlex
SEMA3C
Tbio
Novelty:  0.00828813
p_int:  0.991541059
p_ni:  0.008273882
p_wrong:  0.000185059
Score:  0.212
Data Source:  BioPlex,STRINGDB
COL14A1
Tbio
Novelty:  0.01760399
p_int:  0.990133439
p_ni:  0.00986656
p_wrong:  2e-9
Score:  0.166
Data Source:  BioPlex,STRINGDB
PXYLP1
Tbio
Family:  Enzyme
Novelty:  0.04672634
p_int:  0.976147025
p_ni:  0.023591093
p_wrong:  0.000261882
Data Source:  BioPlex
SULF2
Tbio
Family:  Enzyme
Novelty:  0.01536228
p_int:  0.97231979
p_ni:  0.027680091
p_wrong:  1.19e-7
Score:  0.524
Data Source:  BioPlex,STRINGDB
HSPA5
Tchem
Novelty:  0.00043424
p_int:  0.96774504
p_ni:  0.03225496
Score:  0.587
Data Source:  BioPlex,STRINGDB
UBR1
Tbio
Family:  Enzyme
Novelty:  0.00998888
p_int:  0.946314856
p_ni:  0.053685144
Data Source:  BioPlex
CHST10
Tbio
Family:  Enzyme
Novelty:  0.06829376
p_int:  0.941505825
p_ni:  0.058492797
p_wrong:  0.000001378
Data Source:  BioPlex
PRSS12
Tchem
Novelty:  0.02726265
p_int:  0.921444542
p_ni:  0.000040009
p_wrong:  0.078515449
Data Source:  BioPlex
ERAP1
Tchem
Family:  Enzyme
Novelty:  0.00404539
p_int:  0.906928059
p_ni:  0.093071941
Score:  0.315
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets (25)
Explore Nearest Tclin Targets
1 – 4 of 4
Pathways (99)
Amyloid fiber formation (R-HSA-977225)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 34
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amyloid fiber formation
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-mediated anterograde transport
Reactome
Developmental Biology
Reactome
ER to Golgi Anterograde Transport
Name
Explore in Pharos
Explore in Source
Amyloid fiber formation
Asparagine N-linked glycosylation
COPI-mediated anterograde transport
Developmental Biology
ER to Golgi Anterograde Transport
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (77)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Disease Associations (null)
No disease associations found
GWAS Traits (35)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
type 1 diabetes mellitus
7
7
3
1.6
99.8
type 2 diabetes mellitus
12
12
2
1.2
99.7
6
4
0
1.2
98.2
glomerular filtration rate
7
7
8
7
95.7
birth weight
4
4
4
94.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
type 1 diabetes mellitus
3
1.6
99.8
type 2 diabetes mellitus
2
1.2
99.7
0
1.2
98.2
glomerular filtration rate
8
7
95.7
birth weight
4
94.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
insulin
VGNC:1070
449570
Macaque
insulin
704534
Mouse
MGI:96573
16334
Mouse
MGI:96572
16333
Rat
RGD:2916
24506
Species
Name
OMA
EggNOG
Inparanoid
Chimp
insulin
Macaque
insulin
Mouse
Mouse
Rat
Publication Statistics
PubMed Score 226021.99
PubMed score by year
PubTator Score 62986.53
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title