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Tbio
INPP5K
Inositol polyphosphate 5-phosphatase K

Protein Summary
Description
Inositol 5-phosphatase which acts on inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Has 6-fold higher affinity for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5-trisphosphate (PubMed:10753883). Negatively regulates assembly of the actin cytoskeleton. Controls insulin-dependent glucose uptake among inositol 3,4,5-trisphosphate phosphatases; therefore, is the specific regulator for insulin signaling in skeletal muscle (By similarity). This gene encodes a protein with 5-phosphatase activity toward polyphosphate inositol. The protein localizes to the cytosol in regions lacking actin stress fibers. It is thought that this protein may negatively regulate the actin cytoskeleton. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320345
  • ENSP00000318476
  • ENSG00000132376
  • ENST00000406424
  • ENSP00000385177
  • ENST00000421807
  • ENSP00000413937

Symbol
  • PPS
  • SKIP
  • PPS
  • SKIP
  • MDCCAID
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
disease perturbation
1
molecular function
0.91
histone modification site profile
0.8
virus perturbation
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.18   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 130   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.18   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 48
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (51)
MAD2L1BP
Tbio
Novelty:  0.48374717
p_int:  0.999825188
p_ni:  0.000161274
p_wrong:  0.000013538
Score:  0.228
Data Source:  BioPlex,STRINGDB
KATNA1
Tbio
Family:  Enzyme
Novelty:  0.05656063
p_int:  0.999787683
p_ni:  0.000212256
p_wrong:  6e-8
Score:  0.173
Data Source:  BioPlex,STRINGDB
FBXL19
Tbio
Novelty:  0.07526966
p_int:  0.999464794
p_ni:  0.000535206
Data Source:  BioPlex
USP47
Tchem
Family:  Enzyme
Novelty:  0.07579226
p_int:  0.999352778
p_ni:  0.000647222
Score:  0.152
Data Source:  BioPlex,STRINGDB
RFX1
Tbio
Family:  TF
Novelty:  0.00225236
p_int:  0.971025744
p_ni:  0.028972899
p_wrong:  0.000001357
Data Source:  BioPlex
UBB
Tbio
Novelty:  0.00661254
p_int:  0.968624635
p_ni:  0.031375365
Data Source:  BioPlex
C1orf131
Tdark
Novelty:  10.11904762
p_int:  0.961594197
p_ni:  0.029368027
p_wrong:  0.009037776
Score:  0.187
Data Source:  BioPlex,STRINGDB
AAMP
Tbio
Novelty:  0.0160792
p_int:  0.956985641
p_ni:  0.043014359
Score:  0.234
Data Source:  BioPlex,STRINGDB
PES1
Tbio
Novelty:  0.07162845
p_int:  0.950670481
p_ni:  0.049329519
Data Source:  BioPlex
PROSER2
Tdark
Novelty:  0.56334611
p_int:  0.939184892
p_ni:  0.060815108
Data Source:  BioPlex
Pathways (29)
Metabolism (R-HSA-1430728)

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Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
PI Metabolism
Reactome
Phospholipid metabolism
Reactome
Synthesis of PIPs at the plasma membrane
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
PI Metabolism
Phospholipid metabolism
Synthesis of PIPs at the plasma membrane
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (59)
Find Similar Targets
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations (null)
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
3
3
92.1
lymphocyte percentage of leukocytes
2
3
3
89.6
neutrophil count
3
2
3
80.4
myeloid white cell count
2
2
2
72.4
C-reactive protein measurement
2
2
2
68.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
92.1
lymphocyte percentage of leukocytes
3
89.6
neutrophil count
3
80.4
myeloid white cell count
2
72.4
C-reactive protein measurement
2
68.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
inositol polyphosphate-5-phosphatase K
VGNC:9334
454410
Macaque
inositol polyphosphate-5-phosphatase K
721222
Mouse
MGI:1194899
19062
Rat
RGD:1359130
287533
Dog
inositol polyphosphate-5-phosphatase K
VGNC:42036
480647
Species
Name
OMA
EggNOG
Inparanoid
Chimp
inositol polyphosphate-5-phosphatase K
Macaque
inositol polyphosphate-5-phosphatase K
Mouse
Rat
Dog
inositol polyphosphate-5-phosphatase K
Publication Statistics
PubMed Score 19.18
PubMed score by year
PubTator Score 53.44
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title