INPP5F
Phosphatidylinositide phosphatase SAC2
Protein Summary
Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol, for a sequential dephosphorylation of phosphatidylinositol 4,5-bisphosphate at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling (PubMed:25869669). Regulator of TF:TFRC and integrins recycling pathway, is also involved in cell migration mechanisms (PubMed:25869669). Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation (PubMed:17322895). Negatively regulates STAT3 signaling pathway through inhibition of STAT3 phosphorylation and translocation to the nucleus (PubMed:25476455). Functionally important modulator of cardiac myocyte size and of the cardiac response to stress (By similarity). May play a role as negative regulator of axon regeneration after central nervous system injuries (By similarity). The protein encoded by this gene is an in ...more
- ENST00000361976
- ENSP00000354519
- ENSG00000198825
- ENST00000369080
- ENSP00000358076
- ENST00000369081
- ENSP00000489864
- ENST00000650409
- ENSP00000496955
- ENST00000650623
- ENSP00000497527
- KIAA0966
- SAC2
- SAC2
- hSAC2
- MSTP007
- MSTPO47
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.93 | ||
histone modification site profile | 0.91 | ||
transcription factor binding site profile | 0.82 | ||
pathway | 0.72 | ||
gene perturbation | 0.7 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 6.1 (req: < 5)
Gene RIFs: 6 (req: <= 3)
Antibodies: 86 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 6.1 (req: >= 5)
Gene RIFs: 6 (req: > 3)
Antibodies: 86 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 21
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (78)
Nearest Tclin Targets
Pathways (11)
Reactome (5)
KEGG (3)
PathwayCommons (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism | ||||
Reactome | Metabolism of lipids | ||||
Reactome | PI Metabolism | ||||
Reactome | Phospholipid metabolism | ||||
Reactome | Synthesis of PIPs at the early endosome membrane | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism | ||||
Metabolism of lipids | ||||
PI Metabolism | ||||
Phospholipid metabolism | ||||
Synthesis of PIPs at the early endosome membrane | ||||
Viral Interactions (0)
Gene Ontology Terms (29)
Functions (7)
Components (8)
Processes (14)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | ParkinsonsUK-UCL | |||
Inferred from Direct Assay (IDA) | ParkinsonsUK-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Disease Associations ()
GWAS Traits (13)
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
3 | 2 | 1 | 1.4 | 91.7 | |||||
electrocardiography | 1 | 1 | 10 | 84.6 | |||||
4 | 3 | 1 | 1.6 | 84.4 | |||||
2 | 1 | 0 | 1.4 | 82 | |||||
left ventricular ejection fraction measurement | 3 | 2 | 3 | 81.6 | |||||
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
1 | 1.4 | 91.7 | |||||
electrocardiography | 10 | 84.6 | |||||
1 | 1.6 | 84.4 | |||||
0 | 1.4 | 82 | |||||
left ventricular ejection fraction measurement | 3 | 81.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | inositol polyphosphate-5-phosphatase F | VGNC:7234 | 450780 | |||||
Macaque | inositol polyphosphate-5-phosphatase F | 703808 | ||||||
Mouse | MGI:2141867 | 101490 | ||||||
Rat | RGD:1305777 | 309008 | ||||||
Dog | inositol polyphosphate-5-phosphatase F | VGNC:42034 | 100856192 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | inositol polyphosphate-5-phosphatase F | |||||
Macaque | inositol polyphosphate-5-phosphatase F | |||||
Mouse | ||||||
Rat | ||||||
Dog | inositol polyphosphate-5-phosphatase F | |||||
Publication Statistics
PubMed Score 6.10
PubMed score by year
PubTator Score 18.69
PubTator score by year
Related Publications
Text Mined References (15)
GeneRif Annotations (6)
Items per page:
0 of 0
PMID | Year | Title |
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