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Tbio
INPP4B
Type II inositol 3,4-bisphosphate 4-phosphatase

Protein Summary
Description
Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate (Probable). Plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3,4-bisphosphate in membrane ruffles (PubMed:24591580). INPP4B encodes the inositol polyphosphate 4-phosphatase type II, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate. There is limited data to suggest that the human type II enzyme is subject to alternative splicing, as has been established for the type I enzyme. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262992
  • ENSP00000262992
  • ENSG00000109452
  • ENST00000506217
  • ENSP00000424057
  • ENST00000508116
  • ENSP00000423954
  • ENST00000513000
  • ENSP00000425487
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
PubMedID
0.89
kinase perturbation
0.88
gene perturbation
0.74
histone modification site profile
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.88   (req: < 5)
Gene RIFs: 46   (req: <= 3)
Antibodies: 113   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.88   (req: >= 5)
Gene RIFs: 46   (req: > 3)
Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (76)
PTEN
Tchem
Family:  Enzyme
Novelty:  0.00013818
Score:  0.98
Data Source:  STRINGDB
INPPL1
Tchem
Family:  Enzyme
Novelty:  0.00634126
Score:  0.955
Data Source:  STRINGDB
INPP5J
Tbio
Family:  Enzyme
Novelty:  0.0537284
Score:  0.955
Data Source:  STRINGDB
INPP5K
Tbio
Family:  Enzyme
Novelty:  0.07282504
Score:  0.951
Data Source:  STRINGDB
PIK3C3
Tchem
Family:  Kinase
Novelty:  0.00269825
Score:  0.946
Data Source:  STRINGDB
INPP5B
Tbio
Family:  Enzyme
Novelty:  0.02981249
Score:  0.946
Data Source:  STRINGDB
PIK3R1
Tchem
Family:  Kinase
Novelty:  0.00179772
Score:  0.945
Data Source:  STRINGDB
OCRL
Tbio
Family:  Enzyme
Novelty:  0.00555539
Score:  0.941
Data Source:  STRINGDB
INPP5A
Tchem
Family:  Enzyme
Novelty:  0.03249263
Score:  0.932
Data Source:  STRINGDB
INPP5D
Tbio
Family:  Enzyme
Novelty:  0.00630254
Score:  0.932
Data Source:  STRINGDB
Pathways (16)
Inositol phosphate metabolism (R-HSA-1483249)

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Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Inositol phosphate metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
PI Metabolism
Reactome
Phospholipid metabolism
Name
Explore in Pharos
Explore in Source
Inositol phosphate metabolism
Metabolism
Metabolism of lipids
PI Metabolism
Phospholipid metabolism
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
3
4
90.5
smoking initiation
2
2
2
83.2
plasminogen activator inhibitor 1 measurement
2
2
0
465.7
77.8
alcohol consumption measurement
6
4
6
77.3
risk-taking behaviour
3
3
3
55.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
4
90.5
smoking initiation
2
83.2
plasminogen activator inhibitor 1 measurement
0
465.7
77.8
alcohol consumption measurement
6
77.3
risk-taking behaviour
3
55.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
inositol polyphosphate-4-phosphatase type II B
461514
Macaque
inositol polyphosphate-4-phosphatase type II B
699738
Mouse
MGI:2158925
234515
Rat
RGD:620470
116699
Dog
inositol polyphosphate-4-phosphatase type II B
VGNC:42029
476072
Species
Name
OMA
EggNOG
Inparanoid
Chimp
inositol polyphosphate-4-phosphatase type II B
Macaque
inositol polyphosphate-4-phosphatase type II B
Mouse
Rat
Dog
inositol polyphosphate-4-phosphatase type II B
Publication Statistics
PubMed Score 66.88
PubMed score by year
PubTator Score 43.56
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title