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Tbio
INPP1
Inositol polyphosphate 1-phosphatase

Protein Summary
Description
This gene encodes the enzyme inositol polyphosphate-1-phosphatase, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 1 of the inositol ring from the polyphosphates inositol 1,4-bisphosphate and inositol 1,3,4-trisphophosphate. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322522
  • ENSP00000325423
  • ENSG00000151689
  • ENST00000392329
  • ENSP00000376142
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.93
transcription factor perturbation
0.84
disease perturbation
0.79
tissue sample
0.68
histone modification site profile
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.45   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 139   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.45   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (61)
IMPA2
Tbio
Family:  Enzyme
Novelty:  0.03983031
Score:  0.96
Data Source:  STRINGDB
IMPA1
Tclin
Family:  Enzyme
Novelty:  0.00766053
Score:  0.96
Data Source:  STRINGDB
INPP4A
Tbio
Family:  Enzyme
Novelty:  0.03714963
Score:  0.946
Data Source:  STRINGDB
ITPK1
Tbio
Family:  Kinase
Novelty:  0.02790263
Score:  0.939
Data Source:  STRINGDB
INPP5J
Tbio
Family:  Enzyme
Novelty:  0.0537284
Score:  0.936
Data Source:  STRINGDB
INPP4B
Tbio
Family:  Enzyme
Novelty:  0.02053228
Score:  0.928
Data Source:  STRINGDB
SYNJ2
Tchem
Novelty:  0.03679911
Score:  0.926
Data Source:  STRINGDB
SYNJ1
Tchem
Novelty:  0.01030746
Score:  0.924
Data Source:  STRINGDB
INPP5F
Tbio
Family:  Enzyme
Novelty:  0.1881586
Score:  0.921
Data Source:  STRINGDB
IMPAD1
Tbio
Family:  Enzyme
Novelty:  0.08211251
Score:  0.92
Data Source:  STRINGDB
Pathways (10)
Inositol phosphate metabolism (R-HSA-1483249)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Inositol phosphate metabolism
Reactome
Metabolism
Reactome
Synthesis of IP2, IP, and Ins in the cytosol
Name
Explore in Pharos
Explore in Source
Inositol phosphate metabolism
Metabolism
Synthesis of IP2, IP, and Ins in the cytosol
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lifestyle measurement
1
1
1
58.4
platelet count
1
1
1
47.7
insomnia measurement
2
1
0
1
35
glomerular filtration rate
1
1
0
5.5
17.8
platelet crit
1
1
1
12.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lifestyle measurement
1
58.4
platelet count
1
47.7
insomnia measurement
0
1
35
glomerular filtration rate
0
5.5
17.8
platelet crit
1
12.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
inositol polyphosphate-1-phosphatase
VGNC:1978
460106
Macaque
inositol polyphosphate-1-phosphatase
703301
Mouse
MGI:104848
16329
Rat
RGD:1306071
316376
Dog
inositol polyphosphate-1-phosphatase
VGNC:42027
478842
Species
Name
OMA
EggNOG
Inparanoid
Chimp
inositol polyphosphate-1-phosphatase
Macaque
inositol polyphosphate-1-phosphatase
Mouse
Rat
Dog
inositol polyphosphate-1-phosphatase
Publication Statistics
PubMed Score 18.45
PubMed score by year
PubTator Score 19.07
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title