Tdark INO80E INO80 complex subunit E

Protein Summary

Description

Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

Uniprot Accession IDs

• Q8NBZ0
• Q6Y2K3

Gene Name

• INO80E

Ensembl ID

• ENST00000562441
• ENSP00000456073
• ENSG00000169592
• ENST00000563197
• ENSP00000457016
• ENST00000567065
• ENSP00000454665
• ENST00000620599
• ENSP00000484187

Symbol

• CCDC95
• CCDC95

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.88
histone modification site profile	0.83
cell type or tissue	0.7
cellular component	0.68
transcription factor perturbation	0.68

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.78   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 14   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.78   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 14   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (90)

Explore Interacting Targets

1 – 10 of 90

• See Interactions on String-DB

INO80

Tbio

Family:  Enzyme

Novelty:  0.09412936

p_int:  0.999999968

p_ni:  2.9e-8

p_wrong:  3e-9

Score:  0.999

Data Source:  BioPlex,STRINGDB

UCHL5

Tbio

Family:  Enzyme

Novelty:  0.01486265

p_int:  0.999999743

p_ni:  2.56e-7

p_wrong:  1e-9

Score:  0.967

Data Source:  BioPlex,STRINGDB

INO80C

Tdark

Novelty:  0.04242834

p_int:  0.999999245

p_ni:  7.55e-7

Score:  0.951

Data Source:  BioPlex,STRINGDB

CCNDBP1

Tbio

Novelty:  0.01527762

p_int:  0.999985679

p_ni:  0.000013647

p_wrong:  6.73e-7

Score:  0.738

Data Source:  BioPlex,STRINGDB

RUVBL2

Tbio

Novelty:  0.01129017

p_int:  0.99997186

p_ni:  0.000002119

p_wrong:  0.000026021

Score:  0.968

Data Source:  BioPlex,STRINGDB

RUVBL1

Tbio

Novelty:  0.0089115

p_int:  0.999769743

p_ni:  9.48e-7

p_wrong:  0.000229309

Score:  0.972

Data Source:  BioPlex,STRINGDB

BCL7A

Tbio

Novelty:  0.07026394

p_int:  0.997135862

p_ni:  0.000337103

p_wrong:  0.002527035

Score:  0.19

Data Source:  BioPlex,STRINGDB

ACTR5

Tbio

Novelty:  0.15502033

Score:  0.999

Data Source:  STRINGDB

NFRKB

Tbio

Novelty:  0.13445983

Score:  0.999

Data Source:  STRINGDB

MCRS1

Tbio

Novelty:  0.03404119

Score:  0.974

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (8)

Reactome (8)

DNA Damage Recognition in GG-NER (R-HSA-5696394)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	DNA Damage Recognition in GG-NER	38 targets	R-HSA-5696394
Reactome	DNA Repair	306 targets	R-HSA-73894
Reactome	Deubiquitination	278 targets	R-HSA-5688426
Reactome	Global Genome Nucleotide Excision Repair (GG-NER)	84 targets	R-HSA-5696399
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499

Name	Explore in Pharos	Explore in Source
DNA Damage Recognition in GG-NER	38 targets	R-HSA-5696394
DNA Repair	306 targets	R-HSA-73894
Deubiquitination	278 targets	R-HSA-5688426
Global Genome Nucleotide Excision Repair (GG-NER)	84 targets	R-HSA-5696399
Metabolism of proteins	2050 targets	R-HSA-392499

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (8)

Components (4)

Processes (4)

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1 – 4 of 4

GO Term	Evidence	Assigned by
Ino80 complex	Inferred from Direct Assay (IDA)	UniProtKB
nucleolus	Inferred from Direct Assay (IDA)	HPA
nucleus	Inferred from Direct Assay (IDA)	HPA
nucleoplasm	Traceable Author Statement (TAS)	Reactome

Disease Associations (null)

No disease associations found

GWAS Traits (49)

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1 – 5 of 49

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body mass index	EFO_0004340	6	5	6		96.4
appendicular lean mass	EFO_0004980	2	3	6		94.7
mean corpuscular volume	EFO_0004526	3	2	3		94
waist-hip ratio	EFO_0004343	3	3	3		89.1
red blood cell density measurement	EFO_0007978	2	1	2		87.3

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 49

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body mass index	EFO_0004340	6		96.4
appendicular lean mass	EFO_0004980	6		94.7
mean corpuscular volume	EFO_0004526	3		94
waist-hip ratio	EFO_0004343	3		89.1
red blood cell density measurement	EFO_0007978	2		87.3

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Coiled coil
Complete proteome
DNA damage
DNA recombination
DNA repair
Isopeptide bond
Nucleus
Reference proteome
Transcription

GWAS Trait Find Similar Targets

No Header	No Header
age at menarche
Agents acting on the renin-angiotensin system use measurement
alcohol consumption measurement
alcohol use disorder measurement
anxiety measurement
apolipoprotein A 1 measurement
appendicular lean mass
autism spectrum disorder
bipolar disorder
BMI-adjusted waist circumference

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
growth/size/body region phenotype

IDG Resources

No IDG generated resources found

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	INO80 complex subunit E		708115
Mouse	INO80 complex subunit E	MGI:2141881	233875
Rat	INO80 complex subunit E	RGD:1359572	293494
Dog	INO80 complex subunit E	VGNC:42026	489944
Horse	INO80 complex subunit E	VGNC:19068	100064084

Species	Name	OMA	EggNOG	Inparanoid
Macaque	INO80 complex subunit E
Mouse	INO80 complex subunit E
Rat	INO80 complex subunit E
Dog	INO80 complex subunit E
Horse	INO80 complex subunit E

Publication Statistics

PubMed Score 1.78

PubMed score by year

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PubTator Score 1.09

PubTator score by year

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Related Publications

Text Mined References (13)

GeneRif Annotations (1)

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PMID	Year	Title