Protein Summary
Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.
- ENST00000334598
- ENSP00000334473
- ENSG00000153391
- ENST00000441607
- ENSP00000391457
- ENST00000592173
- ENSP00000465273
- C18orf37
- IES6
- hIes6
- C18orf37
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor binding site profile | 0.92 | ||
transcription factor perturbation | 0.8 | ||
virus perturbation | 0.76 | ||
cellular component | 0.74 | ||
tissue sample | 0.64 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 28.85 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 26 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 28.85 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 26 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (65)
ACTR5
Novelty: 0.15502033
p_int: 0.999999993
p_ni: 7e-9
Score: 0.989
Data Source: BioPlex,STRINGDB
ACTR8
Novelty: 0.12366847
p_int: 0.999999957
p_ni: 4.3e-8
Score: 0.975
Data Source: BioPlex,STRINGDB
INO80B
Novelty: 0.02405051
p_int: 0.999999716
p_ni: 2.84e-7
Score: 0.979
Data Source: BioPlex,STRINGDB
INO80
Family: Enzyme
Novelty: 0.09412936
p_int: 0.999999505
p_ni: 3.12e-7
p_wrong: 1.83e-7
Score: 0.984
Data Source: BioPlex,STRINGDB
INO80D
Novelty: 0.33070971
p_int: 0.999999365
p_ni: 6.19e-7
p_wrong: 1.6e-8
Score: 0.426
Data Source: BioPlex,STRINGDB
INO80E
Novelty: 0.38735443
p_int: 0.999999245
p_ni: 7.55e-7
Score: 0.951
Data Source: BioPlex,STRINGDB
NFRKB
Novelty: 0.13445983
p_int: 0.999998526
p_ni: 0.000001474
Score: 0.939
Data Source: BioPlex,STRINGDB
BCL7C
Novelty: 0.31203802
p_int: 0.999991182
p_ni: 0.00000877
p_wrong: 4.9e-8
Data Source: BioPlex
YY1
Family: TF
Novelty: 0.00120891
p_int: 0.99998191
p_ni: 0.00001809
Score: 0.932
Data Source: BioPlex,STRINGDB
MCRS1
Novelty: 0.03404119
p_int: 0.9999502
p_ni: 0.0000498
Score: 0.947
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (8)
Reactome (8)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | DNA Damage Recognition in GG-NER | ||||
Reactome | DNA Repair | ||||
Reactome | Deubiquitination | ||||
Reactome | Global Genome Nucleotide Excision Repair (GG-NER) | ||||
Reactome | Metabolism of proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
DNA Damage Recognition in GG-NER | ||||
DNA Repair | ||||
Deubiquitination | ||||
Global Genome Nucleotide Excision Repair (GG-NER) | ||||
Metabolism of proteins | ||||
Viral Interactions (0)
Gene Ontology Terms (8)
Components (4)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | HPA | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Disease Associations (null)
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
wellbeing measurement | 3 | 2 | 3 | 31.1 | |||||
heel bone mineral density | 1 | 1 | 1 | 12.9 | |||||
sclerostin measurement | 1 | 1 | 1 | 9.8 | |||||
monocyte count | 1 | 1 | 1 | 6.9 | |||||
neuroticism measurement | 1 | 1 | 1 | 4.5 | |||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
wellbeing measurement | 3 | 31.1 | |||||
heel bone mineral density | 1 | 12.9 | |||||
sclerostin measurement | 1 | 9.8 | |||||
monocyte count | 1 | 6.9 | |||||
neuroticism measurement | 1 | 4.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | INO80 complex subunit C | VGNC:13264 | 455375 | |||||
Macaque | INO80 complex subunit C | 708819 | ||||||
Mouse | MGI:2443014 | 225280 | ||||||
Rat | RGD:1310199 | 291737 | ||||||
Dog | INO80 complex subunit C | 490484 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | INO80 complex subunit C | |||||
Macaque | INO80 complex subunit C | |||||
Mouse | ||||||
Rat | ||||||
Dog | INO80 complex subunit C | |||||
Publication Statistics
PubMed Score 28.85
PubMed score by year
PubTator Score 7.74
PubTator score by year
Related Publications
Text Mined References (11)
GeneRif Annotations (2)
Items per page:
0 of 0
PMID | Year | Title |
|---|