You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
INO80C
INO80 complex subunit C

Protein Summary
Description
Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334598
  • ENSP00000334473
  • ENSG00000153391
  • ENST00000441607
  • ENSP00000391457
  • ENST00000592173
  • ENSP00000465273

Symbol
  • C18orf37
  • IES6
  • hIes6
  • C18orf37
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.92
transcription factor perturbation
0.8
virus perturbation
0.76
cellular component
0.74
tissue sample
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.85   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 26   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.85   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 26   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (65)
ACTR5
Tbio
Novelty:  0.15502033
p_int:  0.999999993
p_ni:  7e-9
Score:  0.989
Data Source:  BioPlex,STRINGDB
ACTR8
Tbio
Novelty:  0.12366847
p_int:  0.999999957
p_ni:  4.3e-8
Score:  0.975
Data Source:  BioPlex,STRINGDB
INO80B
Tbio
Novelty:  0.02405051
p_int:  0.999999716
p_ni:  2.84e-7
Score:  0.979
Data Source:  BioPlex,STRINGDB
INO80
Tbio
Family:  Enzyme
Novelty:  0.09412936
p_int:  0.999999505
p_ni:  3.12e-7
p_wrong:  1.83e-7
Score:  0.984
Data Source:  BioPlex,STRINGDB
INO80D
Tdark
Novelty:  0.33070971
p_int:  0.999999365
p_ni:  6.19e-7
p_wrong:  1.6e-8
Score:  0.426
Data Source:  BioPlex,STRINGDB
INO80E
Tdark
Novelty:  0.38735443
p_int:  0.999999245
p_ni:  7.55e-7
Score:  0.951
Data Source:  BioPlex,STRINGDB
NFRKB
Tbio
Novelty:  0.13445983
p_int:  0.999998526
p_ni:  0.000001474
Score:  0.939
Data Source:  BioPlex,STRINGDB
BCL7C
Tdark
Novelty:  0.31203802
p_int:  0.999991182
p_ni:  0.00000877
p_wrong:  4.9e-8
Data Source:  BioPlex
YY1
Tbio
Family:  TF
Novelty:  0.00120891
p_int:  0.99998191
p_ni:  0.00001809
Score:  0.932
Data Source:  BioPlex,STRINGDB
MCRS1
Tbio
Novelty:  0.03404119
p_int:  0.9999502
p_ni:  0.0000498
Score:  0.947
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
DNA Damage Recognition in GG-NER (R-HSA-5696394)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Damage Recognition in GG-NER
Reactome
DNA Repair
Reactome
Deubiquitination
Reactome
Global Genome Nucleotide Excision Repair (GG-NER)
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
DNA Damage Recognition in GG-NER
DNA Repair
Deubiquitination
Global Genome Nucleotide Excision Repair (GG-NER)
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
wellbeing measurement
3
2
3
31.1
heel bone mineral density
1
1
1
12.9
sclerostin measurement
1
1
1
9.8
monocyte count
1
1
1
6.9
neuroticism measurement
1
1
1
4.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
wellbeing measurement
3
31.1
heel bone mineral density
1
12.9
sclerostin measurement
1
9.8
monocyte count
1
6.9
neuroticism measurement
1
4.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
INO80 complex subunit C
VGNC:13264
455375
Macaque
INO80 complex subunit C
708819
Mouse
MGI:2443014
225280
Rat
RGD:1310199
291737
Dog
INO80 complex subunit C
490484
Species
Name
OMA
EggNOG
Inparanoid
Chimp
INO80 complex subunit C
Macaque
INO80 complex subunit C
Mouse
Rat
Dog
INO80 complex subunit C
Publication Statistics
PubMed Score 28.85
PubMed score by year
PubTator Score 7.74
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title