Tbio INO80 Chromatin-remodeling ATPase INO80

Protein Summary

Description

ATPase component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and DNA repair (PubMed:16230350, PubMed:16298340, PubMed:17721549, PubMed:20855601, PubMed:20237820). Binds DNA (PubMed:16298340, PubMed:21303910). As part of the INO80 complex, remodels chromatin by shifting nucleosomes (PubMed:16230350, PubMed:21303910). Regulates transcription upon recruitment by YY1 to YY1-activated genes, where it acts as an essential coactivator (PubMed:17721549). Involved in UV-damage excision DNA repair (PubMed:20855601). The contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation (PubMed:20687897). Involved in DNA replication (PubMed:20237820). Required for microtubule assembly during mitosis thereby regulating chromosome segregation cycle (PubMed:20237820). This gene encodes a subunit of the chromatin remodeling complex, which is classified into subfamilies depending on sequence features apart from the conserved ATPase domain. This protein is the catalytic ATPase subunit of the INO80 chromatin remodeling complex, which is characterized by a DNA-binding domain. This protein is proposed to bind DNA and be recruited by the YY1 transcription factor to activate certain genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Uniprot Accession IDs

• Q9ULG1
• A6H8X4
• Q9NTG6
• hINO80

Gene Name

• INO80

Ensembl ID

• ENST00000361937
• ENSP00000355205
• ENSG00000128908
• ENST00000401393
• ENSP00000384686
• ENST00000648947
• ENSP00000497609

Symbol

• INO80A
• INOC1
• KIAA1259
• INOC1
• INO80A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.98
transcription factor binding site profile	0.95
histone modification site profile	0.92
hub protein	0.9
virus perturbation	0.88

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.87   (req: < 5)

Gene RIFs: 34   (req: <= 3)

Antibodies: 72   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.87   (req: >= 5)

Gene RIFs: 34   (req: > 3)

Antibodies: 72   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (132)

Explore Interacting Targets

1 – 10 of 132

• See Interactions on String-DB

RUVBL1

Tbio

Novelty:  0.0089115

p_int:  0.999999986

p_ni:  1.3e-8

p_wrong:  1e-9

Score:  0.998

Data Source:  BioPlex,STRINGDB

ACTR8

Tbio

Novelty:  0.12366847

p_int:  0.99999998

p_ni:  2e-8

Score:  0.992

Data Source:  BioPlex,STRINGDB

INO80B

Tbio

Novelty:  0.02405051

p_int:  0.999999976

p_ni:  2.4e-8

Score:  0.993

Data Source:  BioPlex,STRINGDB

INO80E

Tdark

Novelty:  0.38735443

p_int:  0.999999968

p_ni:  2.9e-8

p_wrong:  3e-9

Score:  0.999

Data Source:  BioPlex,STRINGDB

ACTR5

Tbio

Novelty:  0.15502033

p_int:  0.999999564

p_ni:  4.36e-7

Score:  0.999

Data Source:  BioPlex,STRINGDB

INO80C

Tdark

Novelty:  0.04242834

p_int:  0.999999505

p_ni:  3.12e-7

p_wrong:  1.83e-7

Score:  0.984

Data Source:  BioPlex,STRINGDB

BCL7C

Tdark

Novelty:  0.31203802

p_int:  0.999999285

p_ni:  7.15e-7

Score:  0.192

Data Source:  BioPlex,STRINGDB

NFRKB

Tbio

Novelty:  0.13445983

p_int:  0.999999185

p_ni:  8.15e-7

Score:  0.997

Data Source:  BioPlex,STRINGDB

INO80D

Tdark

Novelty:  0.33070971

p_int:  0.999998146

p_ni:  0.000001841

p_wrong:  1.3e-8

Score:  0.96

Data Source:  BioPlex,STRINGDB

YY1

Tbio

Family:  TF

Novelty:  0.00120891

p_int:  0.999997748

p_ni:  0.000002252

Score:  0.966

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (9)

Reactome (8)

PathwayCommons (1)

DNA Damage Recognition in GG-NER (R-HSA-5696394)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	DNA Damage Recognition in GG-NER	38 targets	R-HSA-5696394
Reactome	DNA Repair	306 targets	R-HSA-73894
Reactome	Deubiquitination	278 targets	R-HSA-5688426
Reactome	Global Genome Nucleotide Excision Repair (GG-NER)	84 targets	R-HSA-5696399
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499

Name	Explore in Pharos	Explore in Source
DNA Damage Recognition in GG-NER	38 targets	R-HSA-5696394
DNA Repair	306 targets	R-HSA-73894
Deubiquitination	278 targets	R-HSA-5688426
Global Genome Nucleotide Excision Repair (GG-NER)	84 targets	R-HSA-5696399
Metabolism of proteins	2050 targets	R-HSA-392499

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (36)

Functions (7)

Components (9)

Processes (20)

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1 – 7 of 7

GO Term	Evidence	Assigned by
DNA binding	Inferred from Direct Assay (IDA)	UniProtKB
DNA-dependent ATPase activity	Inferred from Direct Assay (IDA)	UniProtKB
alpha-tubulin binding	Inferred from Mutant Phenotype (IMP)	UniProtKB
ATPase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
histone binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
actin binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations (null)

No disease associations found

GWAS Traits (17)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
glomerular filtration rate	EFO_0005208	6	6	6	7.4	96
hemoglobin measurement	EFO_0004509	2	2	2		64.8
intelligence	EFO_0004337	3	2	1	5.6	57.6
hematocrit	EFO_0004348	1	1	1		51.7
BMI-adjusted waist circumference	EFO_0007789	1	2	2		50.6

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
glomerular filtration rate	EFO_0005208	6	7.4	96
hemoglobin measurement	EFO_0004509	2		64.8
intelligence	EFO_0004337	1	5.6	57.6
hematocrit	EFO_0004348	1		51.7
BMI-adjusted waist circumference	EFO_0007789	2		50.6

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Actin-binding
ATP-binding
Cell cycle
Cell division
Chromosome
Complete proteome
Cytoplasm
Cytoskeleton

GWAS Trait Find Similar Targets

No Header	No Header
age at menopause
allergy
asthma
birth weight
BMI-adjusted waist circumference
cognitive function measurement
creatinine measurement
forced expiratory volume
frailty measurement
glomerular filtration rate

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
cardiovascular system phenotype
cellular phenotype
embryo phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
homeostasis/metabolism phenotype
mortality/aging
reproductive system phenotype

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	INO80 complex subunit	VGNC:1927	453346
Mouse	INO80 complex subunit	MGI:1915392	68142
Rat	INO80 complex subunit	RGD:1310969	296084
Dog	INO80 complex subunit	VGNC:42024	478262
Horse	INO80 complex subunit	VGNC:19067	100057033

Species	Name	OMA	EggNOG	Inparanoid
Chimp	INO80 complex subunit
Mouse	INO80 complex subunit
Rat	INO80 complex subunit
Dog	INO80 complex subunit
Horse	INO80 complex subunit

Publication Statistics

PubMed Score 11.87

PubMed score by year

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PubTator Score 61.67

PubTator score by year

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Related Publications

Text Mined References (49)

GeneRif Annotations (34)

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PMID	Year	Title