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Tchem
INMT
Indolethylamine N-methyltransferase

Protein Summary
Description
Functions as thioether S-methyltransferase and is active with a variety of thioethers and the corresponding selenium and tellurium compounds, including 3-methylthiopropionaldehyde, dimethyl selenide, dimethyl telluride, 2-methylthioethylamine, 2-methylthioethanol, methyl-n-propyl sulfide and diethyl sulfide. Plays an important role in the detoxification of selenium compounds (By similarity). Catalyzes the N-methylation of tryptamine and structurally related compounds. N-methylation of endogenous and xenobiotic compounds is a major method by which they are degraded. This gene encodes an enzyme that N-methylates indoles such as tryptamine. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream FAM188B (family with sequence similarity 188, member B) gene. [provided by RefSeq, Nov 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000013222
  • ENSP00000013222
  • ENSG00000241644
  • ENST00000409539
  • ENSP00000386961

Symbol
  • TEMT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.87
small molecule perturbation
0.71
kinase perturbation
0.48
tissue sample
0.47
chemical
0.46


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.16   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 139   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.16   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (24)
IDO1
Tchem
Family:  Enzyme
Novelty:  0.00131229
Score:  0.933
Data Source:  STRINGDB
IDO2
Tchem
Family:  Enzyme
Novelty:  0.01141558
Score:  0.925
Data Source:  STRINGDB
MAOB
Tclin
Family:  Enzyme
Novelty:  0.00030366
Score:  0.921
Data Source:  STRINGDB
AOC1
Tchem
Family:  Enzyme
Novelty:  0.00146464
Score:  0.921
Data Source:  STRINGDB
MAOA
Tclin
Family:  Enzyme
Novelty:  0.00031037
Score:  0.917
Data Source:  STRINGDB
DDC
Tclin
Family:  Enzyme
Novelty:  0.0012284
Score:  0.904
Data Source:  STRINGDB
AANAT
Tbio
Family:  Enzyme
Novelty:  0.0039709
Score:  0.9
Data Source:  STRINGDB
DMTN
Tbio
Novelty:  0.01330153
Score:  0.676
Data Source:  STRINGDB
MINDY4
Tdark
Novelty:  0.55864743
Score:  0.63
Data Source:  STRINGDB
TIPARP
Tbio
Family:  Enzyme
Novelty:  0.00433138
Score:  0.519
Data Source:  STRINGDB
Pathways (13)
Metabolism (R-HSA-1430728)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Methylation of MeSeH for excretion
Reactome
Selenoamino acid metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of amino acids and derivatives
Methylation of MeSeH for excretion
Selenoamino acid metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1
2
1.1
73
triglyceride measurement
1
1
1
38.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1.1
73
triglyceride measurement
1
38.2
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
indolethylamine N-methyltransferase
463912
Mouse
MGI:102963
21743
Rat
RGD:1597087
368066
Horse
indolethylamine N-methyltransferase
100055070
Cow
indolethylamine N-methyltransferase
527922
Species
Name
OMA
EggNOG
Inparanoid
Chimp
indolethylamine N-methyltransferase
Mouse
Rat
Horse
indolethylamine N-methyltransferase
Cow
indolethylamine N-methyltransferase
Publication Statistics
PubMed Score 55.16
PubMed score by year
PubTator Score 28.49
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title