Tdark INKA2 PAK4-inhibitor INKA2

Protein Summary

Description

Inhibitor of the serine/threonine-protein kinase PAK4. Acts by binding PAK4 in a substrate-like manner, inhibiting the protein kinase activity.

Uniprot Accession IDs

• Q9NTI7
• B3KP38
• B4DF94
• Q9NTI6

Gene Name

• INKA2

Ensembl ID

• ENST00000357260
• ENSP00000349805
• ENSG00000197852

Symbol

• C1orf183
• FAM212B
• FAM212B
• C1orf183

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.87
transcription factor binding site profile	0.8
transcription factor	0.72
cell type or tissue	0.63
small molecule perturbation	0.63

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.87   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 114   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.87   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 114   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (14)

Explore Interacting Targets

1 – 10 of 14

• See Interactions on String-DB

CEP128

Tbio

Novelty:  0.15843064

p_int:  0.999988334

p_ni:  0.000003978

p_wrong:  0.000007688

Score:  0.54

Data Source:  BioPlex,STRINGDB

CDC42BPB

Tchem

Family:  Kinase

Novelty:  0.12012285

p_int:  0.999857487

p_ni:  0.000142513

Score:  0.309

Data Source:  BioPlex,STRINGDB

DNASE1L2

Tbio

Family:  Enzyme

Novelty:  0.0152658

p_int:  0.99985646

p_ni:  0.000143533

p_wrong:  7e-9

Score:  0.211

Data Source:  BioPlex,STRINGDB

CDC42BPA

Tchem

Family:  Kinase

Novelty:  0.02575412

p_int:  0.999691477

p_ni:  0.000308523

Score:  0.309

Data Source:  BioPlex,STRINGDB

TMEM169

Tdark

Novelty:  5.1578082

Score:  0.733

Data Source:  STRINGDB

CTPS1

Tbio

Family:  Enzyme

Novelty:  0.00911596

Score:  0.645

Data Source:  STRINGDB

CTPS2

Tbio

Family:  Enzyme

Novelty:  0.06147923

Score:  0.626

Data Source:  STRINGDB

RSRP1

Tdark

Novelty:  0.74980508

Score:  0.593

Data Source:  STRINGDB

UBALD2

Tdark

Novelty:  2.21418301

Score:  0.553

Data Source:  STRINGDB

C2orf80

Tdark

Novelty:  1.08283503

Score:  0.55

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (3)

Functions (2)

Components (1)

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1 – 2 of 2

GO Term	Evidence	Assigned by
protein kinase binding	Inferred from Physical Interaction (IPI)	UniProtKB
protein serine/threonine kinase inhibitor activity	Inferred from Sequence or structural Similarity (ISS)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (15)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 15

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body mass index	EFO_0004340	4	3	4		84.6
electrocardiography	EFO_0004327	1	2	52		81.2
self reported educational attainment	EFO_0004784	2	3	3		70.9
waist-hip ratio	EFO_0004343	2	2	2		70.4
atrial fibrillation	EFO_0000275	2	1	0	1.1	63.7

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 15

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body mass index	EFO_0004340	4		84.6
electrocardiography	EFO_0004327	52		81.2
self reported educational attainment	EFO_0004784	3		70.9
waist-hip ratio	EFO_0004343	2		70.4
atrial fibrillation	EFO_0000275	0	1.1	63.7

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UniProt Keyword Find Similar Targets

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Complete proteome
Nucleus
Reference proteome

GWAS Trait Find Similar Targets

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atrial fibrillation
body height
body mass index
C-reactive protein measurement
Crohn's disease
electrocardiography
intelligence
lymphocyte count
mathematical ability
multisite chronic pain

MGI Phenotype Find Similar Targets

No Header	No Header
limbs/digits/tail phenotype
skeleton phenotype

IDG Resources

No IDG generated resources found

Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	inka box actin regulator 2	VGNC:10627	469407
Mouse	family with sequence similarity 212, member B	MGI:1923497	109050
Rat	inka box actin regulator 2	RGD:1306526	310764
Horse	inka box actin regulator 2	VGNC:49409	100063508
Cow	inka box actin regulator 2	VGNC:50127	616754

Species	Name	OMA	EggNOG	Inparanoid
Chimp	inka box actin regulator 2
Mouse	family with sequence similarity 212, member B
Rat	inka box actin regulator 2
Horse	inka box actin regulator 2
Cow	inka box actin regulator 2

Publication Statistics

PubMed Score 2.87

PubMed score by year

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Related Publications

Text Mined References (8)

GeneRif Annotations (2)

Items per page:

10

0 of 0

PMID	Year	Title