Protein Summary
Inhibitor of the serine/threonine-protein kinase PAK4. Acts by binding PAK4 in a substrate-like manner, inhibiting the protein kinase activity.
- ENST00000357260
- ENSP00000349805
- ENSG00000197852
- C1orf183
- FAM212B
- FAM212B
- C1orf183
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
histone modification site profile | 0.87 | ||
transcription factor binding site profile | 0.8 | ||
transcription factor | 0.72 | ||
cell type or tissue | 0.63 | ||
small molecule perturbation | 0.63 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2.87 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 114 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2.87 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 114 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (14)
CEP128
Novelty: 0.15843064
p_int: 0.999988334
p_ni: 0.000003978
p_wrong: 0.000007688
Score: 0.54
Data Source: BioPlex,STRINGDB
CDC42BPB
Family: Kinase
Novelty: 0.12012285
p_int: 0.999857487
p_ni: 0.000142513
Score: 0.309
Data Source: BioPlex,STRINGDB
DNASE1L2
Family: Enzyme
Novelty: 0.0152658
p_int: 0.99985646
p_ni: 0.000143533
p_wrong: 7e-9
Score: 0.211
Data Source: BioPlex,STRINGDB
CDC42BPA
Family: Kinase
Novelty: 0.02575412
p_int: 0.999691477
p_ni: 0.000308523
Score: 0.309
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (3)
Functions (2)
Components (1)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Disease Associations ()
GWAS Traits (15)
Items per page:
1 – 5 of 15
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
body mass index | 4 | 3 | 4 | 84.6 | |||||
electrocardiography | 1 | 2 | 52 | 81.2 | |||||
self reported educational attainment | 2 | 3 | 3 | 70.9 | |||||
waist-hip ratio | 2 | 2 | 2 | 70.4 | |||||
2 | 1 | 0 | 1.1 | 63.7 | |||||
Items per page:
1 – 5 of 15
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
body mass index | 4 | 84.6 | |||||
electrocardiography | 52 | 81.2 | |||||
self reported educational attainment | 3 | 70.9 | |||||
waist-hip ratio | 2 | 70.4 | |||||
0 | 1.1 | 63.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | inka box actin regulator 2 | VGNC:10627 | 469407 | |||||
Mouse | MGI:1923497 | 109050 | ||||||
Rat | RGD:1306526 | 310764 | ||||||
Horse | inka box actin regulator 2 | VGNC:49409 | 100063508 | |||||
Cow | inka box actin regulator 2 | VGNC:50127 | 616754 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | inka box actin regulator 2 | |||||
Mouse | ||||||
Rat | ||||||
Horse | inka box actin regulator 2 | |||||
Cow | inka box actin regulator 2 | |||||
Publication Statistics
PubMed Score 2.87
PubMed score by year
Related Publications
Text Mined References (8)
GeneRif Annotations (2)
Items per page:
0 of 0
PMID | Year | Title |
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