Tdark INKA2 PAK4-inhibitor INKA2

Protein Summary

Description

Inhibitor of the serine/threonine-protein kinase PAK4. Acts by binding PAK4 in a substrate-like manner, inhibiting the protein kinase activity.

Uniprot Accession IDs

• Q9NTI7
• B3KP38
• B4DF94
• Q9NTI6

Gene Name

• INKA2

Ensembl ID

• ENST00000357260
• ENSP00000349805
• ENSG00000197852

Symbol

• C1orf183
• FAM212B
• FAM212B
• C1orf183

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.87
transcription factor binding site profile	0.8
transcription factor	0.72
cell type or tissue	0.63
small molecule perturbation	0.63

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.04   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 114   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.04   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 114   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0