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Tbio
INIP
SOSS complex subunit C

Protein Summary
Description
Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. The protein encoded by this gene is a subunit of single-stranded DNA binding complexes that are important for maintaining genome stability. These complexes are involved in G2/M checkpoint control and homologous recombination repair. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374242
  • ENSP00000363360
  • ENSG00000148153

Symbol
  • C9orf80
  • SSBIP1
  • MISE
  • SOSSC
  • SSBIP1
  • C9orf80
  • HSPC043
  • hSSBIP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.82
transcription factor binding site profile
0.79
kinase perturbation
0.71
transcription factor perturbation
0.68
tissue
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.77   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 27   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.77   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 27   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (31)
NABP2
Tbio
Novelty:  0.09046897
p_int:  0.999999996
p_ni:  3e-9
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
SIGLECL1
Tdark
p_int:  0.997496028
p_ni:  0.000469514
p_wrong:  0.002034458
Data Source:  BioPlex
PNKD
Tbio
Family:  Enzyme
Novelty:  0.02456078
p_int:  0.950040225
p_ni:  0.000020272
p_wrong:  0.049939503
Data Source:  BioPlex
COMTD1
Tdark
Family:  Enzyme
Novelty:  0.245971
p_int:  0.840746974
p_ni:  0.000003236
p_wrong:  0.159249789
Score:  0.167
Data Source:  BioPlex,STRINGDB
INTS3
Tbio
Novelty:  0.13398603
Score:  0.999
Data Source:  STRINGDB
NABP1
Tbio
Novelty:  0.09485689
Score:  0.978
Data Source:  STRINGDB
SSBP1
Tbio
Novelty:  0.01105839
Score:  0.905
Data Source:  STRINGDB
SSBP2
Tbio
Novelty:  0.06546999
Score:  0.904
Data Source:  STRINGDB
NBN
Tbio
Novelty:  0.00759456
Score:  0.75
Data Source:  STRINGDB
RBBP8
Tbio
Family:  Enzyme
Novelty:  0.0044233
Score:  0.746
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
1
1
3.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
3.4
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
INTS3 and NABP interacting protein
VGNC:4764
464665
Mouse
MGI:1913459
66209
Rat
RGD:1307983
298032
Dog
INTS3 and NABP interacting protein
VGNC:49804
481671
Horse
INTS3 and NABP interacting protein
VGNC:19066
100629181
Species
Name
OMA
EggNOG
Inparanoid
Chimp
INTS3 and NABP interacting protein
Mouse
Rat
Dog
INTS3 and NABP interacting protein
Horse
INTS3 and NABP interacting protein
Publication Statistics
PubMed Score 23.77
PubMed score by year
PubTator Score 9.21
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title