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Tbio
ING3
Inhibitor of growth protein 3

Protein Summary
Description
Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finge ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000315870
  • ENSP00000320566
  • ENSG00000071243
  • ENST00000339121
  • ENSP00000341697
  • ENST00000427726
  • ENSP00000410406

Symbol
  • Eaf4
  • ING2
  • MEAF4
  • p47ING3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.92
protein domain
0.92
transcription factor binding site profile
0.86
cellular component
0.8
disease perturbation
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.7   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 220   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.7   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 220   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (126)
FOXR2
Tbio
Family:  TF
Novelty:  0.06548862
p_int:  0.999999756
p_ni:  2.43e-7
p_wrong:  1e-9
Score:  0.697
Data Source:  BioPlex,STRINGDB
RUVBL1
Tbio
Novelty:  0.0089115
p_int:  0.999999672
p_ni:  3.28e-7
Score:  0.97
Data Source:  BioPlex,STRINGDB
JADE2
Tbio
Family:  Epigenetic
Novelty:  0.19820849
p_int:  0.999999523
p_ni:  4.77e-7
Score:  0.625
Data Source:  BioPlex,STRINGDB
MEAF6
Tbio
Novelty:  0.0914094
p_int:  0.999999335
p_ni:  6.64e-7
p_wrong:  1e-9
Score:  0.994
Data Source:  BioPlex,STRINGDB
MYCL
Tbio
Family:  TF
Novelty:  0.0034508
p_int:  0.999999259
p_ni:  7.41e-7
Score:  0.749
Data Source:  BioPlex,STRINGDB
H2AFZ
Tbio
Novelty:  0.00222512
p_int:  0.999990871
p_ni:  0.000009129
Score:  0.536
Data Source:  BioPlex,STRINGDB
RUVBL2
Tbio
Novelty:  0.01129017
p_int:  0.999988239
p_ni:  0.000011761
Score:  0.981
Data Source:  BioPlex,STRINGDB
DMAP1
Tbio
Family:  Enzyme
Novelty:  0.03152166
p_int:  0.999973314
p_ni:  0.000026686
Score:  0.986
Data Source:  BioPlex,STRINGDB
YEATS4
Tbio
Novelty:  0.02632024
p_int:  0.999973038
p_ni:  0.000026962
Score:  0.99
Data Source:  BioPlex,STRINGDB
MRGBP
Tbio
Novelty:  0.09537142
p_int:  0.999954874
p_ni:  0.000045126
Score:  0.993
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
HATs acetylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
HATs acetylate histones
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
3
3
91.9
mean reticulocyte volume
1
1
1
37.7
migraine disorder
1
1
0
1
25.4
bone density
1
1
1
11.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
91.9
mean reticulocyte volume
1
37.7
migraine disorder
0
1
25.4
bone density
1
11.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
inhibitor of growth family member 3
VGNC:4401
463679
Macaque
inhibitor of growth family member 3
694005
Mouse
MGI:1919027
71777
Rat
RGD:1310556
312154
Dog
inhibitor of growth family member 3
VGNC:42018
475299
Species
Name
OMA
EggNOG
Inparanoid
Chimp
inhibitor of growth family member 3
Macaque
inhibitor of growth family member 3
Mouse
Rat
Dog
inhibitor of growth family member 3
Publication Statistics
PubMed Score 81.70
PubMed score by year
PubTator Score 16.77
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title