You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
ING2
Inhibitor of growth protein 2

Protein Summary
Description
Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs). This gene is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302327
  • ENSP00000307183
  • ENSG00000168556

Symbol
  • ING1L
  • ING1L
  • p33ING2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
biological process
0.94
virus perturbation
0.94
histone modification site profile
0.87
kinase perturbation
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.51   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 281   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.51   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 281   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (118)
SINHCAF
Tdark
Novelty:  0.18692832
p_int:  1
Score:  0.972
Data Source:  BioPlex,STRINGDB
SIN3B
Tbio
Novelty:  0.04097105
p_int:  0.999999947
p_ni:  5.3e-8
Score:  0.949
Data Source:  BioPlex,STRINGDB
ARID4B
Tbio
Family:  TF; Epigenetic
Novelty:  0.04182223
p_int:  0.99999993
p_ni:  7e-8
Score:  0.898
Data Source:  BioPlex,STRINGDB
SAP130
Tdark
Family:  Enzyme
Novelty:  1.85084032
p_int:  0.999999907
p_ni:  9.3e-8
Score:  0.943
Data Source:  BioPlex,STRINGDB
HDAC1
Tclin
Family:  Epigenetic
Novelty:  0.00065244
p_int:  0.999999903
p_ni:  9.7e-8
Score:  0.979
Data Source:  BioPlex,STRINGDB
RBBP7
Tbio
Novelty:  0.01795364
p_int:  0.999999673
p_ni:  3.27e-7
Score:  0.984
Data Source:  BioPlex,STRINGDB
CENPH
Tbio
Novelty:  0.02845079
p_int:  0.999999566
p_ni:  4.34e-7
Data Source:  BioPlex
BRMS1L
Tbio
Novelty:  0.01578276
p_int:  0.999999352
p_ni:  6.48e-7
Score:  0.964
Data Source:  BioPlex,STRINGDB
SUDS3
Tbio
Family:  Enzyme
Novelty:  0.03837881
p_int:  0.999999215
p_ni:  7.85e-7
Score:  0.971
Data Source:  BioPlex,STRINGDB
ARID4A
Tbio
Family:  TF; Epigenetic
Novelty:  0.04953333
p_int:  0.999999209
p_ni:  7.91e-7
Score:  0.91
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (15)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism of proteins
Reactome
PI5P Regulates TP53 Acetylation
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism of proteins
PI5P Regulates TP53 Acetylation
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (30)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
inhibitor of growth family member 2
VGNC:3835
461625
Macaque
inhibitor of growth family member 2
701839
Mouse
MGI:1916510
69260
Rat
RGD:1307347
290744
Dog
inhibitor of growth family member 2
VGNC:42017
482916
Species
Name
OMA
EggNOG
Inparanoid
Chimp
inhibitor of growth family member 2
Macaque
inhibitor of growth family member 2
Mouse
Rat
Dog
inhibitor of growth family member 2
Publication Statistics
PubMed Score 44.51
PubMed score by year
PubTator Score 911.14
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title