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Tbio
INF2
Inverted formin-2

Protein Summary
Description
Severs actin filaments and accelerates their polymerization and depolymerization. This gene represents a member of the formin family of proteins. It is considered a diaphanous formin due to the presence of a diaphanous inhibitory domain located at the N-terminus of the encoded protein. Studies of a similar mouse protein indicate that the protein encoded by this locus may function in polymerization and depolymerization of actin filaments. Mutations at this locus have been associated with focal segmental glomerulosclerosis 5.[provided by RefSeq, Aug 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330634
  • ENSP00000376406
  • ENSG00000203485
  • ENST00000392634
  • ENSP00000376410
  • ENST00000398337
  • ENSP00000381380

Symbol
  • C14orf151
  • C14orf173
  • FSGS5
  • CMTDIE
  • pp9484
  • C14orf151
  • C14orf173
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
protein domain
0.92
transcription factor perturbation
0.84
transcription factor
0.82
small molecule perturbation
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.97   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 168   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.97   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 168   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0