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Tbio
INF2
Inverted formin-2

Protein Summary
Description
Severs actin filaments and accelerates their polymerization and depolymerization. This gene represents a member of the formin family of proteins. It is considered a diaphanous formin due to the presence of a diaphanous inhibitory domain located at the N-terminus of the encoded protein. Studies of a similar mouse protein indicate that the protein encoded by this locus may function in polymerization and depolymerization of actin filaments. Mutations at this locus have been associated with focal segmental glomerulosclerosis 5.[provided by RefSeq, Aug 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330634
  • ENSP00000376406
  • ENSG00000203485
  • ENST00000392634
  • ENSP00000376410
  • ENST00000398337
  • ENSP00000381380

Symbol
  • C14orf151
  • C14orf173
  • FSGS5
  • CMTDIE
  • pp9484
  • C14orf151
  • C14orf173
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
protein domain
0.92
transcription factor perturbation
0.84
transcription factor
0.82
small molecule perturbation
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 115.68   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 168   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 115.68   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 168   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (88)
PFN2
Tbio
Novelty:  0.00605366
p_int:  0.999999885
p_ni:  1.15e-7
Score:  0.793
Data Source:  BioPlex,STRINGDB
PIP
Tbio
Novelty:  0.00208509
p_int:  0.999999803
p_ni:  1.97e-7
Data Source:  BioPlex
RSPRY1
Tdark
Novelty:  0.26883105
p_int:  0.999996743
p_ni:  2.3e-8
p_wrong:  0.000003234
Score:  0.159
Data Source:  BioPlex,STRINGDB
TMOD3
Tbio
Novelty:  0.04744699
p_int:  0.999996276
p_ni:  0.000003475
p_wrong:  2.49e-7
Score:  0.265
Data Source:  BioPlex,STRINGDB
CD2AP
Tbio
Novelty:  0.00603034
Score:  0.801
Data Source:  STRINGDB
CDC42
Tchem
Family:  Enzyme
Novelty:  0.00032619
Score:  0.776
Data Source:  STRINGDB
ACTN4
Tbio
Novelty:  0.0040236
Score:  0.772
Data Source:  STRINGDB
NPHS2
Tbio
Novelty:  0.00212981
Score:  0.759
Data Source:  STRINGDB
PLCE1
Tbio
Family:  Enzyme
Novelty:  0.0070258
Score:  0.752
Data Source:  STRINGDB
TRPC6
Tchem
Family:  IC
Novelty:  0.00118598
Score:  0.712
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
2
4
4
96.8
high density lipoprotein cholesterol measurement
8
6
10
96.5
sex hormone-binding globulin measurement
6
2
6
84.4
neutrophil count
1
1
1
27.3
vitamin C measurement
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
4
96.8
high density lipoprotein cholesterol measurement
10
96.5
sex hormone-binding globulin measurement
6
84.4
neutrophil count
1
27.3
vitamin C measurement
1
24.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
inverted formin, FH2 and WH2 domain containing
VGNC:3403
101059574
Mouse
MGI:1917685
70435
Rat
Dog
inverted formin, FH2 and WH2 domain containing
490877
Horse
inverted formin, FH2 and WH2 domain containing
VGNC:52397
100061064
Species
Name
OMA
EggNOG
Inparanoid
Chimp
inverted formin, FH2 and WH2 domain containing
Mouse
Rat
Dog
inverted formin, FH2 and WH2 domain containing
Horse
inverted formin, FH2 and WH2 domain containing
Publication Statistics
PubMed Score 115.68
PubMed score by year
PubTator Score 93.50
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title