Protein Summary
Severs actin filaments and accelerates their polymerization and depolymerization. This gene represents a member of the formin family of proteins. It is considered a diaphanous formin due to the presence of a diaphanous inhibitory domain located at the N-terminus of the encoded protein. Studies of a similar mouse protein indicate that the protein encoded by this locus may function in polymerization and depolymerization of actin filaments. Mutations at this locus have been associated with focal segmental glomerulosclerosis 5.[provided by RefSeq, Aug 2010]
- ENST00000330634
- ENSP00000376406
- ENSG00000203485
- ENST00000392634
- ENSP00000376410
- ENST00000398337
- ENSP00000381380
- C14orf151
- C14orf173
- FSGS5
- CMTDIE
- pp9484
- C14orf151
- C14orf173
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 1 | ||
protein domain | 0.92 | ||
transcription factor perturbation | 0.84 | ||
transcription factor | 0.82 | ||
small molecule perturbation | 0.79 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 115.68 (req: < 5)
Gene RIFs: 30 (req: <= 3)
Antibodies: 168 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 115.68 (req: >= 5)
Gene RIFs: 30 (req: > 3)
Antibodies: 168 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (88)
PFN2
Novelty: 0.00605366
p_int: 0.999999885
p_ni: 1.15e-7
Score: 0.793
Data Source: BioPlex,STRINGDB
RSPRY1
Novelty: 0.26883105
p_int: 0.999996743
p_ni: 2.3e-8
p_wrong: 0.000003234
Score: 0.159
Data Source: BioPlex,STRINGDB
TMOD3
Novelty: 0.04744699
p_int: 0.999996276
p_ni: 0.000003475
p_wrong: 2.49e-7
Score: 0.265
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (1)
WikiPathways (1)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
WikiPathways | Primary Focal Segmental Glomerulosclerosis FSGS | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Primary Focal Segmental Glomerulosclerosis FSGS | ||||
Viral Interactions (0)
Gene Ontology Terms (5)
Functions (2)
Components (1)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
apolipoprotein A 1 measurement | 2 | 4 | 4 | 96.8 | |||||
high density lipoprotein cholesterol measurement | 8 | 6 | 10 | 96.5 | |||||
sex hormone-binding globulin measurement | 6 | 2 | 6 | 84.4 | |||||
neutrophil count | 1 | 1 | 1 | 27.3 | |||||
vitamin C measurement | 1 | 1 | 1 | 24.5 | |||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
apolipoprotein A 1 measurement | 4 | 96.8 | |||||
high density lipoprotein cholesterol measurement | 10 | 96.5 | |||||
sex hormone-binding globulin measurement | 6 | 84.4 | |||||
neutrophil count | 1 | 27.3 | |||||
vitamin C measurement | 1 | 24.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | inverted formin, FH2 and WH2 domain containing | VGNC:3403 | 101059574 | |||||
Mouse | MGI:1917685 | 70435 | ||||||
Rat | ||||||||
Dog | inverted formin, FH2 and WH2 domain containing | 490877 | ||||||
Horse | inverted formin, FH2 and WH2 domain containing | VGNC:52397 | 100061064 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | inverted formin, FH2 and WH2 domain containing | |||||
Mouse | ||||||
Rat | ||||||
Dog | inverted formin, FH2 and WH2 domain containing | |||||
Horse | inverted formin, FH2 and WH2 domain containing | |||||
Publication Statistics
PubMed Score 115.68
PubMed score by year
PubTator Score 93.50
PubTator score by year
Related Publications
Text Mined References (39)
GeneRif Annotations (30)
Items per page:
0 of 0
PMID | Year | Title |
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