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Tbio
INAVA
Innate immunity activator protein

Protein Summary
Description
Expressed in peripheral macrophages and intestinal myeloid-derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion (PubMed:28436939). In the intestine, regulates adherens junction stability by regulating the degradation of CYTH1 and CYTH2, probably acting as substrate cofactor for SCF E3 ubiquitin-protein ligase complexes. Stabilizes adherens junctions by limiting CYTH1-dependent ARF6 activation (PubMed:29420262).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367342
  • ENSP00000356311
  • ENSG00000163362
  • ENST00000413687
  • ENSP00000392105

Symbol
  • C1orf106
  • C1orf106
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.11   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 102   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.11   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (46)
CYTH2
Tbio
Novelty:  0.03560664
p_int:  0.999999299
p_ni:  7.01e-7
Score:  0.316
Data Source:  BioPlex,STRINGDB
CALCOCO2
Tbio
Novelty:  0.01456844
p_int:  0.99999833
p_ni:  0.00000167
Data Source:  BioPlex
CYTH1
Tbio
Novelty:  0.00635156
p_int:  0.999996585
p_ni:  0.000003415
Score:  0.392
Data Source:  BioPlex,STRINGDB
CYTH3
Tbio
Novelty:  0.00940752
p_int:  0.999970809
p_ni:  0.000029182
p_wrong:  9e-9
Score:  0.316
Data Source:  BioPlex,STRINGDB
PPP2R3B
Tbio
Family:  Enzyme
Novelty:  0.02932064
p_int:  0.999593619
p_ni:  0.00040638
Score:  0.181
Data Source:  BioPlex,STRINGDB
TAX1BP3
Tbio
Novelty:  0.01605171
p_int:  0.998785304
p_ni:  0.001214695
p_wrong:  1e-9
Score:  0.308
Data Source:  BioPlex,STRINGDB
DCTN5
Tbio
Novelty:  0.19530162
p_int:  0.997144293
p_ni:  0.002852133
p_wrong:  0.000003574
Score:  0.555
Data Source:  BioPlex,STRINGDB
CRTAP
Tbio
Novelty:  0.02380647
p_int:  0.996930411
p_ni:  0.003069589
Score:  0.185
Data Source:  BioPlex,STRINGDB
DCTN6
Tdark
Novelty:  0.30624393
p_int:  0.995257352
p_ni:  0.004742397
p_wrong:  2.51e-7
Score:  0.555
Data Source:  BioPlex,STRINGDB
CEP170
Tbio
Novelty:  0.05342931
p_int:  0.993523871
p_ni:  0.006476129
Score:  0.241
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (18)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
2
1
1.2
90.3
3
3
0
1.1
88.9
2
2
0
1.2
83.4
1
1
0
1.2
80.6
creatinine measurement
1
1
1
67.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.2
90.3
0
1.1
88.9
0
1.2
83.4
0
1.2
80.6
creatinine measurement
1
67.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
innate immunity activator
VGNC:10555
101058404
Mouse
MGI:1921579
67313
Rat
RGD:1311892
289399
Dog
uncharacterized protein C1orf106
100855825
Horse
innate immunity activator
VGNC:19056
100063112
Species
Name
OMA
EggNOG
Inparanoid
Chimp
innate immunity activator
Mouse
Rat
Dog
uncharacterized protein C1orf106
Horse
innate immunity activator
Publication Statistics
PubMed Score 7.11
PubMed score by year
PubTator Score 1.50
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title