Protein Summary
Class-IV neuronal intermediate filament that is able to self-assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NF-L to form the filamentous backbone to which NF-M and NF-H attach to form the cross-bridges. Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene is a member of the intermediate filament family and is involved in the morphogenesis of neurons. [provided by RefSeq, Jun 2009]
- ENST00000369849
- ENSP00000358865
- ENSG00000148798
- NEF5
- NEF5
- NF-66
- TXBP-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.88 | ||
PubMedID | 0.82 | ||
gene perturbation | 0.71 | ||
cellular component | 0.7 | ||
tissue sample | 0.69 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 130.9 (req: < 5)
Gene RIFs: 18 (req: <= 3)
Antibodies: 444 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 130.9 (req: >= 5)
Gene RIFs: 18 (req: > 3)
Antibodies: 444 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (53)
NEFM
Novelty: 0.00239134
p_int: 0.999999748
p_ni: 2.52e-7
Score: 0.83
Data Source: BioPlex,STRINGDB
VIM
Novelty: 0.00030317
p_int: 0.999996709
p_ni: 0.000003291
Score: 0.817
Data Source: BioPlex,STRINGDB
SYNC
Novelty: 0.04605223
p_int: 0.999993008
p_ni: 0.000006992
Score: 0.311
Data Source: BioPlex,STRINGDB
RSPRY1
Novelty: 0.26883105
p_int: 0.999964273
p_ni: 0.000035727
Score: 0.215
Data Source: BioPlex,STRINGDB
NEFH
Novelty: 0.0013027
p_int: 0.999937342
p_ni: 0.000062658
Score: 0.4
Data Source: BioPlex,STRINGDB
GFAP
Novelty: 0.00020932
p_int: 0.999717474
p_ni: 0.000282526
Score: 0.692
Data Source: BioPlex,STRINGDB
MIPEP
Family: Enzyme
Novelty: 0.01507033
p_int: 0.998265147
p_ni: 0.001734853
Data Source: BioPlex
CCDC183
Novelty: 1.55719016
p_int: 0.994619905
p_ni: 0.005380092
p_wrong: 3e-9
Data Source: BioPlex
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (16)
Functions (3)
Components (9)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (22)
Items per page:
1 – 5 of 22
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
worry measurement | 2 | 3 | 2 | 7.2 | 72.1 | ||||
body height | 1 | 1 | 1 | 69.2 | |||||
1 | 2 | 2 | 68.4 | ||||||
pulse pressure measurement | 1 | 1 | 1 | 67.9 | |||||
cortical surface area measurement | 1 | 1 | 0 | 773.2 | 67.1 | ||||
Items per page:
1 – 5 of 22
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
worry measurement | 2 | 7.2 | 72.1 | ||||
body height | 1 | 69.2 | |||||
2 | 68.4 | ||||||
pulse pressure measurement | 1 | 67.9 | |||||
cortical surface area measurement | 0 | 773.2 | 67.1 | ||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | internexin neuronal intermediate filament protein alpha | VGNC:5479 | 450709 | |||||
Macaque | internexin neuronal intermediate filament protein alpha | 714455 | ||||||
Mouse | MGI:96568 | 226180 | ||||||
Rat | RGD:2911 | 24503 | ||||||
Dog | internexin neuronal intermediate filament protein alpha | VGNC:42014 | 486869 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | internexin neuronal intermediate filament protein alpha | |||||
Macaque | internexin neuronal intermediate filament protein alpha | |||||
Mouse | ||||||
Rat | ||||||
Dog | internexin neuronal intermediate filament protein alpha | |||||
Publication Statistics
PubMed Score 130.90
PubMed score by year
PubTator Score 263.69
PubTator score by year
Related Publications
Text Mined References (32)
GeneRif Annotations (18)
Items per page:
0 of 0
PMID | Year | Title |
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