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Tbio
IMPAD1
Inositol monophosphatase 3

Protein Summary
Description
May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation. This gene encodes a member of the inositol monophosphatase family. The encoded protein is localized to the Golgi apparatus and catalyzes the hydrolysis of phosphoadenosine phosphate (PAP) to adenosine monophosphate (AMP). Mutations in this gene are a cause of GRAPP type chondrodysplasia with joint dislocations, and a pseudogene of this gene is located on the long arm of chromosome 1. [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262644
  • ENSP00000262644
  • ENSG00000104331

Symbol
  • IMPA3
  • GPAPP
  • IMP 3
  • IMP-3
  • IMPA3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
kinase perturbation
0.93
disease perturbation
0.87
microRNA
0.68
molecular function
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.33   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 97   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.33   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 97   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (109)
GOLPH3
Tbio
Novelty:  0.00020234
p_int:  0.998839414
p_ni:  0.001146921
p_wrong:  0.000013666
Data Source:  BioPlex
PTCH1
Tbio
Novelty:  0.00077635
p_int:  0.997553639
p_ni:  0.002446361
Score:  0.166
Data Source:  BioPlex,STRINGDB
GOLPH3L
Tbio
Novelty:  0.30373124
p_int:  0.995757608
p_ni:  0.002093241
p_wrong:  0.002149151
Data Source:  BioPlex
CSGALNACT2
Tbio
Family:  Enzyme
Novelty:  0.0770692
p_int:  0.994903178
p_ni:  0.005096821
p_wrong:  1e-9
Data Source:  BioPlex
TCTN2
Tbio
Novelty:  0.11617528
p_int:  0.99294569
p_ni:  0.00705431
Data Source:  BioPlex
EFNA5
Tbio
Novelty:  0.00134985
p_int:  0.992573232
p_ni:  0.007426766
p_wrong:  2e-9
Data Source:  BioPlex
C1orf198
Tdark
Novelty:  3.89427313
p_int:  0.968409345
p_ni:  0.031587661
p_wrong:  0.000002993
Data Source:  BioPlex
RAB39B
Tbio
Family:  Enzyme
Novelty:  0.02362498
p_int:  0.945345886
p_ni:  0.054647582
p_wrong:  0.000006532
Data Source:  BioPlex
CD1B
Tbio
Novelty:  0.00102701
p_int:  0.931134626
p_ni:  0.068864977
p_wrong:  3.98e-7
Data Source:  BioPlex
HTR3C
Tchem
Family:  IC
Novelty:  0.112097
p_int:  0.916178023
p_ni:  0.083821977
Data Source:  BioPlex
Pathways (12)
Biological oxidations (R-HSA-211859)

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Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Cytosolic sulfonation of small molecules
Reactome
Metabolism
Reactome
Phase II - Conjugation of compounds
Name
Explore in Pharos
Explore in Source
Biological oxidations
Cytosolic sulfonation of small molecules
Metabolism
Phase II - Conjugation of compounds
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (22)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
1
0
1.6
77.6
brain measurement
1
1
0
6.2
4.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
0
1.6
77.6
brain measurement
0
6.2
4.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
inositol monophosphatase domain containing 1
VGNC:861
464188
Macaque
inositol monophosphatase domain containing 1
696893
Mouse
MGI:1915720
242291
Dog
inositol monophosphatase domain containing 1
VGNC:42009
477890
Horse
inositol monophosphatase domain containing 1 [Source:HGNC Symbol;Acc:HGNC:26019]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
inositol monophosphatase domain containing 1
Macaque
inositol monophosphatase domain containing 1
Mouse
Dog
inositol monophosphatase domain containing 1
Horse
inositol monophosphatase domain containing 1 [Source:HGNC Symbol;Acc:HGNC:26019]
Publication Statistics
PubMed Score 20.33
PubMed score by year
PubTator Score 3.42
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title