Tbio IMMT MICOS complex subunit MIC60

Protein Summary

Description

Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:22114354, PubMed:25781180).

Uniprot Accession IDs

• Q16891
• B1H0U5
• B2R5N6
• Q14539
• Q15092
• Q68D41
• Q69HW5
• Q6IBL0
• Q7Z3X1
• Q8TAJ5
• Q9P0V2

Gene Name

• IMMT

Ensembl ID

• ENST00000410111
• ENSP00000387262
• ENSG00000132305
• ENST00000442664
• ENSP00000407788
• ENST00000449247
• ENSP00000396899

Symbol

• HMP
• MIC60
• MINOS2
• HMP
• P87
• P89
• PIG4
• Mic60
• PIG52
• MINOS2
• P87/89
• MICOS60

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
interacting protein	1
co-expressed gene	0.96
virus perturbation	0.95
kinase perturbation	0.93

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 396.41   (req: < 5)

Gene RIFs: 23   (req: <= 3)

Antibodies: 313   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 396.41   (req: >= 5)

Gene RIFs: 23   (req: > 3)

Antibodies: 313   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0