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Tbio
ILVBL
Acetolactate synthase-like protein

Protein Summary
Description
The protein encoded by this gene shares similarity with several thiamine pyrophosphate-binding proteins identified in bacteria, yeast, and plants. The highest degree of similarity is found with bacterial acetolactate synthases (AHAS), which are enzymes that catalyze the first step in branched-chain amino acid biosynthesis. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263383
  • ENSP00000263383
  • ENSG00000105135

Symbol
  • AHAS
  • AHAS
  • 209L8
  • ILV2H
  • HACL1L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
protein domain
0.85
virus perturbation
0.85
co-expressed gene
0.79
transcription factor perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 413.78   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 278   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 413.78   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 278   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (52)
GBA2
Tchem
Family:  Enzyme
Novelty:  0.01340895
p_int:  0.999998916
p_ni:  7.63e-7
p_wrong:  3.21e-7
Score:  0.412
Data Source:  BioPlex,STRINGDB
DPEP1
Tclin
Family:  Enzyme
Novelty:  0.00384946
p_int:  0.999617275
p_ni:  0.000382725
Data Source:  BioPlex
OSBPL6
Tbio
Novelty:  0.25692861
p_int:  0.998548627
p_ni:  0.001451373
Data Source:  BioPlex
OSBPL3
Tbio
Novelty:  0.06106368
p_int:  0.976323069
p_ni:  0.023676931
Data Source:  BioPlex
THADA
Tbio
Novelty:  0.06983966
p_int:  0.972746757
p_ni:  0.027253243
Score:  0.254
Data Source:  BioPlex,STRINGDB
XPO6
Tbio
Novelty:  0.03229708
p_int:  0.951944582
p_ni:  0.047671246
p_wrong:  0.000384172
Data Source:  BioPlex
INTS12
Tbio
Family:  Epigenetic
Novelty:  0.09023473
p_int:  0.921489698
p_ni:  0.078510151
p_wrong:  1.51e-7
Score:  0.313
Data Source:  BioPlex,STRINGDB
INTS1
Tbio
Novelty:  0.17523407
p_int:  0.888652905
p_ni:  0.111347094
p_wrong:  1e-9
Score:  0.614
Data Source:  BioPlex,STRINGDB
XPO4
Tbio
Novelty:  0.01507446
p_int:  0.886708768
p_ni:  0.113291232
Data Source:  BioPlex
C5AR2
Tbio
Family:  GPCR
Novelty:  0.01193736
p_int:  0.872186924
p_ni:  0.127813076
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: panther
Isoleucine biosynthesis
PathwayCommons: panther
Valine biosynthesis
Name
Explore in Pharos
Explore in Source
Isoleucine biosynthesis
Valine biosynthesis
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pulse pressure measurement
1
1
1
57.7
Anti-Toxoplasma gondii IgG measurement
1
1
1
12.1
platelet crit
2
1
2
11.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pulse pressure measurement
1
57.7
Anti-Toxoplasma gondii IgG measurement
1
12.1
platelet crit
2
11.9
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ilvB acetolactate synthase like
VGNC:13188
455791
Macaque
ilvB acetolactate synthase like
718086
Mouse
MGI:1351911
216136
Rat
RGD:1307988
362843
Dog
ilvB acetolactate synthase like
VGNC:42003
100856083
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ilvB acetolactate synthase like
Macaque
ilvB acetolactate synthase like
Mouse
Rat
Dog
ilvB acetolactate synthase like
Publication Statistics
PubMed Score 413.78
PubMed score by year
PubTator Score 55.50
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title