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Tchem
ILK
Integrin-linked protein kinase

Protein Summary
Description
Receptor-proximal protein kinase regulating integrin-mediated signal transduction (PubMed:8538749, PubMed:9736715). May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B (PubMed:8538749, PubMed:9736715). This gene encodes a protein with a kinase-like domain and four ankyrin-like repeats. The encoded protein associates at the cell membrane with the cytoplasmic domain of beta integrins, where it regulates integrin-mediated signal transduction. Activity of this protein is important in the epithelial to mesenchymal transition, and over-expression of this gene is implicated in tumor gr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299421
  • ENSP00000299421
  • ENSG00000166333
  • ENST00000396751
  • ENSP00000379975
  • ENST00000420936
  • ENSP00000403487
  • ENST00000528995
  • ENSP00000435323
  • ENST00000532063
  • ENSP00000434492

Symbol
  • ILK1
  • ILK2
  • P59
  • ILK-1
  • ILK-2
  • p59ILK
  • HEL-S-28
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
disease perturbation
0.99
interacting protein
0.99
molecular function
0.99
kinase perturbation
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 849.6   (req: < 5)
Gene RIFs: 216   (req: <= 3)
Antibodies: 727   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 849.6   (req: >= 5)
Gene RIFs: 216   (req: > 3)
Antibodies: 727   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 51
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (213)
PARVA
Tbio
Novelty:  0.02736601
p_int:  1
Score:  0.999
Data Source:  BioPlex,STRINGDB
PARVB
Tbio
Novelty:  0.03825772
p_int:  0.999999995
p_ni:  2e-9
p_wrong:  3e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
RSU1
Tbio
Novelty:  0.01645054
p_int:  0.999999941
p_ni:  5.9e-8
Score:  0.98
Data Source:  BioPlex,STRINGDB
LIMS1
Tbio
Novelty:  0.00648304
p_int:  0.999999658
p_ni:  3.42e-7
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
PARVG
Tbio
Novelty:  0.08921402
p_int:  0.999998993
p_ni:  0.000001007
Score:  0.998
Data Source:  BioPlex,STRINGDB
HSPA8
Tchem
Novelty:  0.00081014
p_int:  0.973192566
p_ni:  0.026807434
Score:  0.566
Data Source:  BioPlex,STRINGDB
HSPA2
Tchem
Novelty:  0.01696667
p_int:  0.940150175
p_ni:  0.059849825
Score:  0.7
Data Source:  BioPlex,STRINGDB
HSPA6
Tbio
Novelty:  0.00654285
p_int:  0.870903695
p_ni:  0.129096305
Score:  0.279
Data Source:  BioPlex,STRINGDB
LIMS2
Tbio
Novelty:  0.0832739
Score:  0.999
Data Source:  Reactome,STRINGDB
PXN
Tbio
Novelty:  0.00082031
Score:  0.995
Data Source:  STRINGDB
Nearest Tclin Targets (4)
Explore Nearest Tclin Targets
Pathways (21)
Cell junction organization (R-HSA-446728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Cell-extracellular matrix interactions
Reactome
Localization of the PINCH-ILK-PARVIN complex to focal adhesions
Name
Explore in Pharos
Explore in Source
Cell junction organization
Cell-Cell communication
Cell-extracellular matrix interactions
Localization of the PINCH-ILK-PARVIN complex to focal adhesions
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (66)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
2
2
2
57.7
platelet crit
1
1
1
40.7
mammographic density measurement
1
1
1
1.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
2
57.7
platelet crit
1
40.7
mammographic density measurement
1
1.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
integrin linked kinase
VGNC:11840
748941
Macaque
integrin linked kinase
709944
Mouse
MGI:1195267
16202
Rat
RGD:620063
170922
Dog
integrin linked kinase
VGNC:42001
476836
Species
Name
OMA
EggNOG
Inparanoid
Chimp
integrin linked kinase
Macaque
integrin linked kinase
Mouse
Rat
Dog
integrin linked kinase
Publication Statistics
PubMed Score 849.60
PubMed score by year
PubTator Score 369.83
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title