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Tchem
ILK
Integrin-linked protein kinase

Protein Summary
Description
Receptor-proximal protein kinase regulating integrin-mediated signal transduction (PubMed:8538749, PubMed:9736715). May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B (PubMed:8538749, PubMed:9736715). This gene encodes a protein with a kinase-like domain and four ankyrin-like repeats. The encoded protein associates at the cell membrane with the cytoplasmic domain of beta integrins, where it regulates integrin-mediated signal transduction. Activity of this protein is important in the epithelial to mesenchymal transition, and over-expression of this gene is implicated in tumor gr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299421
  • ENSP00000299421
  • ENSG00000166333
  • ENST00000396751
  • ENSP00000379975
  • ENST00000420936
  • ENSP00000403487
  • ENST00000528995
  • ENSP00000435323
  • ENST00000532063
  • ENSP00000434492

Symbol
  • ILK1
  • ILK2
  • P59
  • ILK-1
  • ILK-2
  • p59ILK
  • HEL-S-28
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
disease perturbation
0.99
interacting protein
0.99
molecular function
0.99
kinase perturbation
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 944.65   (req: < 5)
Gene RIFs: 216   (req: <= 3)
Antibodies: 727   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 944.65   (req: >= 5)
Gene RIFs: 216   (req: > 3)
Antibodies: 727   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 51
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1