You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
IL7R
Interleukin-7 receptor subunit alpha

Protein Summary
Description
Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP). The protein encoded by this gene is a receptor for interleukin 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukins 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in V(D)J recombination during lymphocyte development. Defects in this gene may be associated with severe combined immunodeficiency (SCID). Alternatively spliced transcript variants have been found. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303115
  • ENSP00000306157
  • ENSG00000168685
  • ENST00000506850
  • ENSP00000421207

Symbol
  • ILRA
  • CD127
  • IL7RA
  • CDW127
  • IL-7R-alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
hub protein
0.98
transcription factor perturbation
0.97
biological process
0.86
disease
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 894.7   (req: < 5)
Gene RIFs: 209   (req: <= 3)
Antibodies: 1128   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 894.7   (req: >= 5)
Gene RIFs: 209   (req: > 3)
Antibodies: 1128   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0