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Tclin
IL6ST
Interleukin-6 receptor subunit beta

Protein Summary
Description
Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates Janus kinases (PubMed:2261637). That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:19915009, PubMed:23294003). Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (By similarity). Has a role in embryonic development (By similarity). Does not bind IL6 (PubMed:2261637). Essential for survival of motor and sensory neurons and for differentiation of astrocytes (By similarity). Required for expression of TRPA1 in nociceptive neurons (By similarity). Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (By similarity). Required for normal trabecular bone ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336909
  • ENSP00000338799
  • ENSG00000134352
  • ENST00000381287
  • ENSP00000370687
  • ENST00000381294
  • ENSP00000370694
  • ENST00000381298
  • ENSP00000370698
  • ENST00000502326
  • ENSP00000462158
  • ENST00000522633
  • ENSP00000435399

Symbol
  • CD130
  • GP130
  • CDW130
  • IL-6RB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.99
biological process
0.97
disease perturbation
0.95
transcription factor binding site profile
0.94
transcription factor perturbation
0.94


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.52   (req: < 5)
Gene RIFs: 164   (req: <= 3)
Antibodies: 694   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.52   (req: >= 5)
Gene RIFs: 164   (req: > 3)
Antibodies: 694   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (159)
OSM
Tbio
Novelty:  0.00227405
p_int:  0.999999776
p_ni:  2.2e-7
p_wrong:  4e-9
Score:  0.985
Data Source:  BioPlex,Reactome,STRINGDB
UPK2
Tbio
Novelty:  0.01066132
p_int:  0.999698426
p_ni:  0.000079661
p_wrong:  0.000221913
Data Source:  BioPlex
VAMP5
Tbio
Novelty:  0.09958312
p_int:  0.992732141
p_ni:  0.000133825
p_wrong:  0.007134034
Data Source:  BioPlex
IL6
Tclin
Novelty:  0.00001819
Score:  0.997
Data Source:  Reactome,STRINGDB
LIF
Tbio
Novelty:  0.00094373
Score:  0.993
Data Source:  Reactome,STRINGDB
IL6R
Tclin
Novelty:  0.00185005
Score:  0.991
Data Source:  Reactome,STRINGDB
STAT3
Tchem
Family:  TF
Novelty:  0.00011808
Score:  0.987
Data Source:  Reactome,STRINGDB
IL11
Tbio
Novelty:  0.00103994
Score:  0.979
Data Source:  Reactome,STRINGDB
CNTF
Tbio
Novelty:  0.00091188
Score:  0.974
Data Source:  Reactome,STRINGDB
JAK1
Tclin
Family:  Kinase
Novelty:  0.00093625
Score:  0.973
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (45)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
IL-6-type cytokine receptor ligand interactions
Reactome
Immune System
Reactome
Interleukin-12 family signaling
Reactome
Interleukin-27 signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
IL-6-type cytokine receptor ligand interactions
Immune System
Interleukin-12 family signaling
Interleukin-27 signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (44)
Find Similar Targets
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
BHF-UCL
Inferred by Curator (IC)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
1
1
38.8
1
1
0
1.2
1.1
Cleft palate
1
1
0
1.2
1.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
38.8
0
1.2
1.1
Cleft palate
0
1.2
1.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interleukin 6 signal transducer
VGNC:13514
461866
Macaque
interleukin 6 signal transducer
574127
Mouse
MGI:96560
16195
Rat
RGD:2903
25205
Dog
interleukin 6 signal transducer
VGNC:41994
403545
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interleukin 6 signal transducer
Macaque
interleukin 6 signal transducer
Mouse
Rat
Dog
interleukin 6 signal transducer
Publication Statistics
PubMed Score 97.52
PubMed score by year
PubTator Score 469.43
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title