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Tclin
IL6ST
Interleukin-6 receptor subunit beta

Protein Summary
Description
Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates Janus kinases (PubMed:2261637). That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:19915009, PubMed:23294003). Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (By similarity). Has a role in embryonic development (By similarity). Does not bind IL6 (PubMed:2261637). Essential for survival of motor and sensory neurons and for differentiation of astrocytes (By similarity). Required for expression of TRPA1 in nociceptive neurons (By similarity). Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (By similarity). Required for normal trabecular bone ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336909
  • ENSP00000338799
  • ENSG00000134352
  • ENST00000381287
  • ENSP00000370687
  • ENST00000381294
  • ENSP00000370694
  • ENST00000381298
  • ENSP00000370698
  • ENST00000502326
  • ENSP00000462158
  • ENST00000522633
  • ENSP00000435399

Symbol
  • CD130
  • GP130
  • CDW130
  • IL-6RB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.99
biological process
0.97
disease perturbation
0.95
transcription factor binding site profile
0.94
transcription factor perturbation
0.94


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 119.12   (req: < 5)
Gene RIFs: 164   (req: <= 3)
Antibodies: 694   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 119.12   (req: >= 5)
Gene RIFs: 164   (req: > 3)
Antibodies: 694   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4