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Tclin
IL6R
Interleukin-6 receptor subunit alpha

Protein Summary
Description
Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity. This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344086
  • ENSP00000340589
  • ENSG00000160712
  • ENST00000368485
  • ENSP00000357470

Symbol
  • IL6Q
  • gp80
  • CD126
  • IL6RA
  • IL6RQ
  • IL-6RA
  • IL-6R-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.99
trait
0.93
PubMedID
0.92
transcription factor binding site profile
0.92
biological process
0.89


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 437.01   (req: < 5)
Gene RIFs: 291   (req: <= 3)
Antibodies: 896   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 437.01   (req: >= 5)
Gene RIFs: 291   (req: > 3)
Antibodies: 896   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 41
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (200)
TBCK
Tbio
Family:  Kinase
Novelty:  0.08568145
p_int:  0.999999977
p_ni:  2e-8
p_wrong:  2e-9
Score:  0.282
Data Source:  BioPlex,STRINGDB
PPP1R21
Tdark
Family:  Enzyme
Novelty:  0.33099657
p_int:  0.999999824
p_ni:  1.76e-7
p_wrong:  1e-9
Score:  0.163
Data Source:  BioPlex,STRINGDB
MID1
Tbio
Family:  Enzyme
Novelty:  0.02400169
p_int:  0.999999686
p_ni:  3.05e-7
p_wrong:  9e-9
Score:  0.197
Data Source:  BioPlex,STRINGDB
C12orf4
Tdark
Novelty:  0.35695485
p_int:  0.999999367
p_ni:  1.06e-7
p_wrong:  5.27e-7
Score:  0.282
Data Source:  BioPlex,STRINGDB
CRYZL1
Tbio
Family:  Enzyme
Novelty:  0.04435286
p_int:  0.999997098
p_ni:  0.000002898
p_wrong:  5e-9
Score:  0.189
Data Source:  BioPlex,STRINGDB
FANCB
Tbio
Novelty:  0.00268111
p_int:  0.999996747
p_ni:  0.000003253
Score:  0.232
Data Source:  BioPlex,STRINGDB
FANCL
Tbio
Family:  Enzyme
Novelty:  0.00274467
p_int:  0.999780291
p_ni:  0.000059712
p_wrong:  0.000159997
Score:  0.345
Data Source:  BioPlex,STRINGDB
FAAP100
Tdark
Novelty:  0.1698504
p_int:  0.998419923
p_ni:  0.001580039
p_wrong:  3.8e-8
Score:  0.183
Data Source:  BioPlex,STRINGDB
CETN2
Tbio
Novelty:  0.00641301
p_int:  0.997236308
p_ni:  0.002763692
Score:  0.179
Data Source:  BioPlex,STRINGDB
COPRS
Tbio
Novelty:  0.03545787
p_int:  0.988584723
p_ni:  0.000301176
p_wrong:  0.011114101
Score:  0.179
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (43)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Developmental Biology
Reactome
Immune System
Reactome
Interleukin-4 and Interleukin-13 signaling
Reactome
Interleukin-6 family signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Developmental Biology
Immune System
Interleukin-4 and Interleukin-13 signaling
Interleukin-6 family signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (52)
Find Similar Targets
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (34)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
9
24
29
11.5
99.9
interleukin-6 measurement
4
5
5
98.9
interleukin 6 receptor subunit alpha measurement
2
2
2
96.3
fibrinogen measurement
5
3
4
5.3
93.9
blood protein measurement
2
2
2
89.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
29
11.5
99.9
interleukin-6 measurement
5
98.9
interleukin 6 receptor subunit alpha measurement
2
96.3
fibrinogen measurement
4
5.3
93.9
blood protein measurement
2
89.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interleukin 6 receptor
VGNC:1271
469506
Macaque
interleukin 6 receptor
716690
Mouse
MGI:105304
16194
Rat
RGD:2902
24499
Dog
interleukin 6 receptor
VGNC:41993
612271
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interleukin 6 receptor
Macaque
interleukin 6 receptor
Mouse
Rat
Dog
interleukin 6 receptor
Publication Statistics
PubMed Score 437.01
PubMed score by year
PubTator Score 796.09
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title