You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
IL6R
Interleukin-6 receptor subunit alpha

Protein Summary
Description
Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity. This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344086
  • ENSP00000340589
  • ENSG00000160712
  • ENST00000368485
  • ENSP00000357470

Symbol
  • IL6Q
  • gp80
  • CD126
  • IL6RA
  • IL6RQ
  • IL-6RA
  • IL-6R-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.99
trait
0.93
PubMedID
0.92
transcription factor binding site profile
0.92
biological process
0.89


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 522.07   (req: < 5)
Gene RIFs: 291   (req: <= 3)
Antibodies: 896   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 522.07   (req: >= 5)
Gene RIFs: 291   (req: > 3)
Antibodies: 896   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 41
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3