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Tclin
IL6
Interleukin-6

Protein Summary
Description
Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation. This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induce ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258743
  • ENSP00000258743
  • ENSG00000136244
  • ENST00000404625
  • ENSP00000385675

Symbol
  • IFNB2
  • CDF
  • HGF
  • HSF
  • BSF2
  • IL-6
  • BSF-2
  • IFNB2
  • IFN-beta-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
1
virus perturbation
1
gene perturbation
0.96


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57274.16   (req: < 5)
Gene RIFs: 3470   (req: <= 3)
Antibodies: 2567   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57274.16   (req: >= 5)
Gene RIFs: 3470   (req: > 3)
Antibodies: 2567   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 67
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 11
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (11)
fosdagrocorat
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US8901310, Comparator B
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US8901310, Comparator E
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US8901310, Comparator C
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US8901310, Comparator F
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US8901310, Comparator D
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US8901310, Comparator G
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US8901310, Comparator J
Rendered image for US8901310, Comparator J
US8901310, Comparator H
Rendered image for US8901310, Comparator H
US8901310, Comparator I
Rendered image for US8901310, Comparator I
Protein-Protein Interactions (1344)
IL6R
Tclin
Novelty:  0.00185005
Score:  0.999
Data Source:  Reactome,STRINGDB
STAT3
Tchem
Family:  TF
Novelty:  0.00011808
Score:  0.997
Data Source:  Reactome,STRINGDB
IL6ST
Tclin
Novelty:  0.01026472
Score:  0.997
Data Source:  Reactome,STRINGDB
IL10
Tbio
Novelty:  0.00004352
Score:  0.997
Data Source:  STRINGDB
IL4
Tbio
Novelty:  0.00005852
Score:  0.996
Data Source:  STRINGDB
SOCS3
Tbio
Novelty:  0.00106095
Score:  0.992
Data Source:  Reactome,STRINGDB
IL13
Tbio
Novelty:  0.00021435
Score:  0.988
Data Source:  STRINGDB
CXCL8
Tchem
Novelty:  0.00005958
Score:  0.985
Data Source:  STRINGDB
JUN
Tchem
Family:  TF
Novelty:  0.00006856
Score:  0.984
Data Source:  STRINGDB
TNF
Tclin
Novelty:  0.00001457
Score:  0.984
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (238)
Cellular Senescence (R-HSA-2559583)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 21
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cellular Senescence
Cellular responses to external stimuli
Cellular responses to stress
Cytokine Signaling in Immune system
Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (30)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
6
6
8
95.6
lymphocyte count
3
2
3
90.1
serum non-albumin protein measurement
2
3
3
87.9
eosinophil count
3
2
3
85.7
pulse pressure measurement
1
1
1
77.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
8
95.6
lymphocyte count
3
90.1
serum non-albumin protein measurement
3
87.9
eosinophil count
3
85.7
pulse pressure measurement
1
77.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interleukin 6
VGNC:4400
463288
Macaque
interleukin 6
705819
Mouse
MGI:96559
16193
Rat
RGD:2901
24498
Dog
interleukin 6
VGNC:41992
403985
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interleukin 6
Macaque
interleukin 6
Mouse
Rat
Dog
interleukin 6
Publication Statistics
PubMed Score 57274.16
PubMed score by year
PubTator Score 26787.89
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title