Protein Summary
Participates in at least several B-cell activation processes as well as of other cell types (PubMed:3016727). It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages (By similarity). Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4 (By similarity). The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune re ...more
- ENST00000231449
- ENSP00000231449
- ENSG00000113520
- ENST00000350025
- ENSP00000325190
- BSF1
- IL-4
- BCGF1
- BSF-1
- BCGF-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
biological term | 1 | ||
chemical | 1 | ||
co-expressed gene | 0.89 | ||
disease | 0.85 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 17041.12 (req: < 5)
Gene RIFs: 779 (req: <= 3)
Antibodies: 1683 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 17041.12 (req: >= 5)
Gene RIFs: 779 (req: > 3)
Antibodies: 1683 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 36
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (685)
Nearest Tclin Targets (19)
Upstream (2)
Downstream (17)
1 – 2 of 2
Pathways (56)
Reactome (6)
KEGG (16)
PathwayCommons (20)
WikiPathways (14)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Immune System | ||||
Reactome | Interleukin-1 family signaling | ||||
Reactome | Interleukin-18 signaling | ||||
Reactome | Interleukin-4 and Interleukin-13 signaling | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cytokine Signaling in Immune system | ||||
Immune System | ||||
Interleukin-1 family signaling | ||||
Interleukin-18 signaling | ||||
Interleukin-4 and Interleukin-13 signaling | ||||
Viral Interactions (0)
Gene Ontology Terms (38)
Functions (3)
Components (2)
Processes (33)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | UniProtKB | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (20)
Items per page:
1 – 5 of 20
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
8 | 11 | 1 | 1.1 | 97.5 | |||||
childhood onset asthma | 3 | 4 | 0 | 1.2 | 96.9 | ||||
eosinophil count | 2 | 3 | 3 | 95.1 | |||||
5 | 6 | 0 | 1.1 | 94.3 | |||||
5 | 5 | 2 | 1.1 | 92.7 | |||||
Items per page:
1 – 5 of 20
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
1 | 1.1 | 97.5 | |||||
childhood onset asthma | 0 | 1.2 | 96.9 | ||||
eosinophil count | 3 | 95.1 | |||||
0 | 1.1 | 94.3 | |||||
2 | 1.1 | 92.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | interleukin 4 | VGNC:4046 | 449565 | |||||
Macaque | interleukin 4 | 574281 | ||||||
Mouse | MGI:96556 | 16189 | ||||||
Rat | RGD:2898 | 287287 | ||||||
Dog | interleukin 4 | VGNC:41987 | 403785 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | interleukin 4 | |||||
Macaque | interleukin 4 | |||||
Mouse | ||||||
Rat | ||||||
Dog | interleukin 4 | |||||
Publication Statistics
PubMed Score 17041.12
PubMed score by year
PubTator Score 6709.36
PubTator score by year
Related Publications
Text Mined References (1113)
GeneRif Annotations (779)
Items per page:
0 of 0
PMID | Year | Title |
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