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Tclin
IL3RA
Interleukin-3 receptor subunit alpha

Protein Summary
Description
This is a receptor for interleukin-3. The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y. Alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jun 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331035
  • ENSP00000327890
  • ENSG00000185291
  • ENST00000381469
  • ENSP00000370878

Symbol
  • IL3R
  • IL3R
  • CD123
  • IL3RX
  • IL3RY
  • IL3RAY
  • hIL-3Ra
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.71
cell type or tissue
0.64
transcription factor
0.64
hub protein
0.63
biological term
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 433.54   (req: < 5)
Gene RIFs: 51   (req: <= 3)
Antibodies: 952   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 433.54   (req: >= 5)
Gene RIFs: 51   (req: > 3)
Antibodies: 952   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (213)
IL3
Tbio
Novelty:  0.0002336
Score:  0.997
Data Source:  Reactome,STRINGDB
CSF2RB
Tclin
Novelty:  0.02093804
Score:  0.982
Data Source:  Reactome,STRINGDB
CSF2
Tbio
Novelty:  0.00010437
Score:  0.972
Data Source:  STRINGDB
STAT5A
Tchem
Family:  TF
Novelty:  0.00074026
Score:  0.961
Data Source:  Reactome,STRINGDB
JAK2
Tclin
Family:  Kinase
Novelty:  0.00022894
Score:  0.96
Data Source:  Reactome,STRINGDB
JAK1
Tclin
Family:  Kinase
Novelty:  0.00093625
Score:  0.953
Data Source:  STRINGDB
IL2
Tchem
Novelty:  0.00003129
Score:  0.95
Data Source:  STRINGDB
IL5
Tclin
Novelty:  0.0001684
Score:  0.944
Data Source:  STRINGDB
IL2RA
Tclin
Novelty:  0.0007607
Score:  0.938
Data Source:  STRINGDB
STAT5B
Tchem
Family:  TF
Novelty:  0.00074178
Score:  0.936
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets (36)
Explore Nearest Tclin Targets
Pathways (129)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
FLT3 Signaling
Reactome
Immune System
Reactome
Interleukin receptor SHC signaling
Reactome
Interleukin-2 family signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
FLT3 Signaling
Immune System
Interleukin receptor SHC signaling
Interleukin-2 family signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
1
3
3
94.7
eosinophil percentage of leukocytes
1
3
3
94.7
mean corpuscular volume
1
1
1
70.2
mitochondrial heteroplasmy measurement
1
1
1
65.4
lymphocyte percentage of leukocytes
1
1
1
60.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
94.7
eosinophil percentage of leukocytes
3
94.7
mean corpuscular volume
1
70.2
mitochondrial heteroplasmy measurement
1
65.4
lymphocyte percentage of leukocytes
1
60.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:96553
16188
Rat
RGD:628728
246144
Dog
interleukin 3 receptor subunit alpha
609293
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
interleukin 3 receptor subunit alpha
Publication Statistics
PubMed Score 433.54
PubMed score by year
PubTator Score 208.44
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title