Tclin IL3RA Interleukin-3 receptor subunit alpha

Protein Summary

Description

This is a receptor for interleukin-3. The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y. Alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jun 2012]

Uniprot Accession IDs

• P26951
• A8K3F3
• B9VI81
• Q5HYQ7
• Q5HYQ8
• Q9UEH7
• IL-3 receptor subunit alpha

Gene Name

• IL3RA

Ensembl ID

• ENST00000331035
• ENSP00000327890
• ENSG00000185291
• ENST00000381469
• ENSP00000370878

Symbol

• IL3R
• IL3R
• CD123
• IL3RX
• IL3RY
• IL3RAY
• hIL-3Ra

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.71
cell type or tissue	0.64
transcription factor	0.64
hub protein	0.63
biological term	0.59

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Cytokine / Interleukin-3 Receptor Subunit Alpha

Protein / Defense/immunity Protein / Interleukin-3 Receptor Subunit Alpha

DTO Classes

Protein / Signaling / Cytokine / Interleukin-3 Receptor Subunit Alpha

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 506.07   (req: < 5)

Gene RIFs: 74   (req: <= 3)

Antibodies: 952   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 506.07   (req: >= 5)

Gene RIFs: 74   (req: > 3)

Antibodies: 952   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1