Tbio IL37 Interleukin-37

Protein Summary

Description

Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation. The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9NZH6
• B5BU97
• Q56AP9
• Q8TD04
• Q8TD05
• Q9HBF2
• Q9HBF3
• Q9UHA6

Gene Name

• IL37

Ensembl ID

• ENST00000263326
• ENSP00000263326
• ENSG00000125571
• ENST00000311328
• ENSP00000309883
• ENST00000349806
• ENSP00000263328
• ENST00000352179
• ENSP00000263327
• ENST00000353225
• ENSP00000309208

Symbol

• FIL1Z
• IL1F7
• IL1H4
• IL1RP1
• FIL1
• FIL1Z
• IL-1H
• IL-37
• IL1F7
• IL1H4
• IL-1F7
• IL-1H4
• IL1RP1
• IL-1RP1
• FIL1(ZETA)

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.58
gene perturbation	0.53
biological term	0.5
cell type or tissue	0.47
phenotype	0.47

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 310.81   (req: < 5)

Gene RIFs: 110   (req: <= 3)

Antibodies: 284   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 310.81   (req: >= 5)

Gene RIFs: 110   (req: > 3)

Antibodies: 284   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (77)

Explore Interacting Targets

1 – 10 of 77

• See Interactions on String-DB

FADD

Tbio

Novelty:  0.00137968

p_int:  0.999723203

p_ni:  0.000276796

p_wrong:  1e-9

Score:  0.578

Data Source:  BioPlex,STRINGDB

HES4

Tbio

Family:  TF

Novelty:  0.05290912

p_int:  0.987897416

p_ni:  0.009555375

p_wrong:  0.002547209

Data Source:  BioPlex

NDUFS5

Tclin

Family:  Enzyme

Novelty:  0.13274675

p_int:  0.979958055

p_ni:  0.01932588

p_wrong:  0.000716065

Data Source:  BioPlex

GPANK1

Tdark

Novelty:  0.20285376

p_int:  0.97835038

p_ni:  0.021022162

p_wrong:  0.000627458

Score:  0.199

Data Source:  BioPlex,STRINGDB

ZSCAN12

Tdark

Family:  TF

Novelty:  0.33578207

p_int:  0.968795095

p_ni:  0.030450684

p_wrong:  0.000754221

Score:  0.179

Data Source:  BioPlex,STRINGDB

FTH1

Tbio

Novelty:  0.000863

p_int:  0.944090058

p_ni:  0.055908359

p_wrong:  0.000001583

Data Source:  BioPlex

CCDC103

Tbio

Novelty:  0.07857649

p_int:  0.931644328

p_ni:  0.068355538

p_wrong:  1.35e-7

Data Source:  BioPlex

BEX5

Tdark

Novelty:  0.2964824

p_int:  0.913156359

p_ni:  0.086836678

p_wrong:  0.000006963

Data Source:  BioPlex

GSG1

Tdark

Novelty:  2.47475466

p_int:  0.892439433

p_ni:  0.107559301

p_wrong:  0.000001266

Score:  0.379

Data Source:  BioPlex,STRINGDB

IL18BP

Tbio

Novelty:  0.00838895

Score:  0.986

Data Source:  Reactome,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (8)

Reactome (6)

KEGG (2)

Cytokine Signaling in Immune system (R-HSA-1280215)

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5

1 – 5 of 6

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Interleukin-1 family signaling	140 targets	R-HSA-446652
Reactome	Interleukin-18 signaling	8 targets	R-HSA-9012546
Reactome	Interleukin-37 signaling	21 targets	R-HSA-9008059

Name	Explore in Pharos	Explore in Source
Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Immune System	2246 targets	R-HSA-168256
Interleukin-1 family signaling	140 targets	R-HSA-446652
Interleukin-18 signaling	8 targets	R-HSA-9012546
Interleukin-37 signaling	21 targets	R-HSA-9008059

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (16)

Functions (2)

Components (5)

Processes (9)

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Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
cytokine activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
interleukin-1 receptor binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations (null)

No disease associations found

GWAS Traits (9)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 9

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
interleukin-1 beta measurement	EFO_0004812	1	68	68		93.3
allergy	EFO_0003785	1	1	0	1	42.3
asthma	EFO_0000270	1	1	0	1	35
Eczema	HP_0000964	2	1	0	1	35
allergic rhinitis	EFO_0005854	2	1	0	1	35

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 9

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
interleukin-1 beta measurement	EFO_0004812	68		93.3
allergy	EFO_0003785	0	1	42.3
asthma	EFO_0000270	0	1	35
Eczema	HP_0000964	0	1	35
allergic rhinitis	EFO_0005854	0	1	35

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Complete proteome
Cytokine
Cytoplasm
Direct protein sequencing
Nucleus
Polymorphism
Reference proteome
Secreted

GWAS Trait Find Similar Targets

No Header	No Header
allergic rhinitis
allergy
asthma
birth weight
C-reactive protein measurement
Eczema
interleukin-1 beta measurement
neutrophil count
serum alanine aminotransferase measurement

IDG Resources

No IDG generated resources found

Orthologs (4)

1 – 4 of 4

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	interleukin 37		700579
Dog	interleukin 37	VGNC:41986	100686057
Horse	interleukin 37	VGNC:19033	100052470
Cow	interleukin 37	VGNC:30160	786493

Species	Name	OMA	EggNOG	Inparanoid
Macaque	interleukin 37
Dog	interleukin 37
Horse	interleukin 37
Cow	interleukin 37

Publication Statistics

PubMed Score 310.81

PubMed score by year

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PubTator Score 362.50

PubTator score by year

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Related Publications

Text Mined References (134)

GeneRif Annotations (110)

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PMID	Year	Title