Protein Summary
Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation. The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
- ENST00000263326
- ENSP00000263326
- ENSG00000125571
- ENST00000311328
- ENSP00000309883
- ENST00000349806
- ENSP00000263328
- ENST00000352179
- ENSP00000263327
- ENST00000353225
- ENSP00000309208
- FIL1Z
- IL1F7
- IL1H4
- IL1RP1
- FIL1
- FIL1Z
- IL-1H
- IL-37
- IL1F7
- IL1H4
- IL-1F7
- IL-1H4
- IL1RP1
- IL-1RP1
- FIL1(ZETA)
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
protein domain | 0.58 | ||
gene perturbation | 0.53 | ||
biological term | 0.5 | ||
cell type or tissue | 0.47 | ||
phenotype | 0.47 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 310.81 (req: < 5)
Gene RIFs: 110 (req: <= 3)
Antibodies: 284 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 310.81 (req: >= 5)
Gene RIFs: 110 (req: > 3)
Antibodies: 284 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (77)
FADD
Novelty: 0.00137968
p_int: 0.999723203
p_ni: 0.000276796
p_wrong: 1e-9
Score: 0.578
Data Source: BioPlex,STRINGDB
HES4
Family: TF
Novelty: 0.05290912
p_int: 0.987897416
p_ni: 0.009555375
p_wrong: 0.002547209
Data Source: BioPlex
NDUFS5
Family: Enzyme
Novelty: 0.13274675
p_int: 0.979958055
p_ni: 0.01932588
p_wrong: 0.000716065
Data Source: BioPlex
GPANK1
Novelty: 0.20285376
p_int: 0.97835038
p_ni: 0.021022162
p_wrong: 0.000627458
Score: 0.199
Data Source: BioPlex,STRINGDB
ZSCAN12
Family: TF
Novelty: 0.33578207
p_int: 0.968795095
p_ni: 0.030450684
p_wrong: 0.000754221
Score: 0.179
Data Source: BioPlex,STRINGDB
FTH1
Novelty: 0.000863
p_int: 0.944090058
p_ni: 0.055908359
p_wrong: 0.000001583
Data Source: BioPlex
CCDC103
Novelty: 0.07857649
p_int: 0.931644328
p_ni: 0.068355538
p_wrong: 1.35e-7
Data Source: BioPlex
BEX5
Novelty: 0.2964824
p_int: 0.913156359
p_ni: 0.086836678
p_wrong: 0.000006963
Data Source: BioPlex
GSG1
Novelty: 2.47475466
p_int: 0.892439433
p_ni: 0.107559301
p_wrong: 0.000001266
Score: 0.379
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (8)
Reactome (6)
KEGG (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Immune System | ||||
Reactome | Interleukin-1 family signaling | ||||
Reactome | Interleukin-18 signaling | ||||
Reactome | Interleukin-37 signaling | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Cytokine Signaling in Immune system | ||||
Immune System | ||||
Interleukin-1 family signaling | ||||
Interleukin-18 signaling | ||||
Interleukin-37 signaling | ||||
Viral Interactions (0)
Gene Ontology Terms (16)
Functions (2)
Components (5)
Processes (9)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations (null)
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
interleukin-1 beta measurement | 1 | 68 | 68 | 93.3 | |||||
1 | 1 | 0 | 1 | 42.3 | |||||
1 | 1 | 0 | 1 | 35 | |||||
Eczema | 2 | 1 | 0 | 1 | 35 | ||||
2 | 1 | 0 | 1 | 35 | |||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
interleukin-1 beta measurement | 68 | 93.3 | |||||
0 | 1 | 42.3 | |||||
0 | 1 | 35 | |||||
Eczema | 0 | 1 | 35 | ||||
0 | 1 | 35 | |||||
Find similar targets by:
IDG Resources
Orthologs (4)
1 – 4 of 4
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Macaque | interleukin 37 | 700579 | ||||||
Dog | interleukin 37 | VGNC:41986 | 100686057 | |||||
Horse | interleukin 37 | VGNC:19033 | 100052470 | |||||
Cow | interleukin 37 | VGNC:30160 | 786493 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Macaque | interleukin 37 | |||||
Dog | interleukin 37 | |||||
Horse | interleukin 37 | |||||
Cow | interleukin 37 | |||||
Publication Statistics
PubMed Score 310.81
PubMed score by year
PubTator Score 362.50
PubTator score by year
Related Publications
Text Mined References (134)
GeneRif Annotations (110)
Items per page:
0 of 0
PMID | Year | Title |
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