Tbio IL37 Interleukin-37

Protein Summary

Description

Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation. The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9NZH6
• B5BU97
• Q56AP9
• Q8TD04
• Q8TD05
• Q9HBF2
• Q9HBF3
• Q9UHA6

Gene Name

• IL37

Ensembl ID

• ENST00000263326
• ENSP00000263326
• ENSG00000125571
• ENST00000311328
• ENSP00000309883
• ENST00000349806
• ENSP00000263328
• ENST00000352179
• ENSP00000263327
• ENST00000353225
• ENSP00000309208

Symbol

• FIL1Z
• IL1F7
• IL1H4
• IL1RP1
• FIL1
• FIL1Z
• IL-1H
• IL-37
• IL1F7
• IL1H4
• IL-1F7
• IL-1H4
• IL1RP1
• IL-1RP1
• FIL1(ZETA)

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.58
gene perturbation	0.53
biological term	0.5
cell type or tissue	0.47
phenotype	0.47

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 350.33   (req: < 5)

Gene RIFs: 213   (req: <= 3)

Antibodies: 284   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 350.33   (req: >= 5)

Gene RIFs: 213   (req: > 3)

Antibodies: 284   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0