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Tbio
IL34
Interleukin-34

Protein Summary
Description
Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1. Interleukin-34 is a cytokine that promotes the differentiation and viability of monocytes and macrophages through the colony-stimulating factor-1 receptor (CSF1R; MIM 164770) (Lin et al., 2008 [PubMed 18467591]).[supplied by OMIM, May 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000288098
  • ENSP00000288098
  • ENSG00000157368
  • ENST00000429149
  • ENSP00000397863

Symbol
  • C16orf77
  • IL-34
  • C16orf77
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.6
tissue sample
0.53
cell type or tissue
0.51
PubMedID
0.5
biological process
0.47


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 201.97   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 350   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 201.97   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 350   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (35)
CSF1R
Tclin
Family:  Kinase
Novelty:  0.00064143
Score:  0.998
Data Source:  Reactome,STRINGDB
CSF1
Tbio
Novelty:  0.0005221
Score:  0.974
Data Source:  Reactome,STRINGDB
PTPRZ1
Tchem
Family:  Enzyme
Novelty:  0.00518159
Score:  0.932
Data Source:  Reactome,STRINGDB
SDC1
Tbio
Novelty:  0.00044792
Score:  0.907
Data Source:  Reactome,STRINGDB
TLR3
Tbio
Novelty:  0.00057048
Score:  0.689
Data Source:  STRINGDB
TRAF3
Tbio
Novelty:  0.0022525
Score:  0.549
Data Source:  STRINGDB
IL1B
Tclin
Novelty:  0.0000308
Score:  0.536
Data Source:  STRINGDB
DNALI1
Tbio
Novelty:  0.13865981
Score:  0.526
Data Source:  STRINGDB
TREM2
Tbio
Novelty:  0.00228007
Score:  0.517
Data Source:  STRINGDB
SPI1
Tbio
Family:  TF
Novelty:  0.00064309
Score:  0.515
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Other interleukin signaling
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Other interleukin signaling
Signaling by Interleukins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cognitive function measurement
3
2
4
69.8
brain measurement
1
1
0
9.2
62.8
alanine measurement
1
1
1
60.3
cortical surface area measurement
1
1
0
8
54.5
brain volume measurement
2
2
2
52
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cognitive function measurement
4
69.8
brain measurement
0
9.2
62.8
alanine measurement
1
60.3
cortical surface area measurement
0
8
54.5
brain volume measurement
2
52
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interleukin 34
VGNC:5809
454217
Macaque
interleukin 34
709034
Mouse
MGI:1923777
76527
Rat
RGD:1586038
498951
Dog
interleukin 34
VGNC:41983
610536
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interleukin 34
Macaque
interleukin 34
Mouse
Rat
Dog
interleukin 34
Publication Statistics
PubMed Score 201.97
PubMed score by year
PubTator Score 65.56
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title