Tbio IL33 Interleukin-33

Protein Summary

Description

Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed:16286016). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury (PubMed:17853410, PubMed:18836528). In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets (PubMed:21734074). This form is rapidely lost upon angiogenic or proinflammatory activation (PubMed:18787100). The protein encoded by this gene is a cytokine that binds to the IL1RL1/ST2 receptor. The encoded protein is involved in the maturation of Th2 cells and the activation of mast cells, basophils, eosinophils and natural killer cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

Uniprot Accession IDs

• O95760
• B2R8L1
• B4DJ35
• B4E1Q9
• D3DRI5
• E7EAX4
• Q2YEJ5
• IL-33

Gene Name

• IL33

Ensembl ID

• ENST00000381434
• ENSP00000370842
• ENSG00000137033
• ENST00000417746
• ENSP00000394039
• ENST00000456383
• ENSP00000414238
• ENST00000611532
• ENSP00000478858

Symbol

• C9orf26
• IL1F11
• NFHEV
• DVS27
• IL1F11
• NF-HEV
• NFEHEV
• C9orf26

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.98
biological term	0.98
gene perturbation	0.98
disease	0.66
phenotype	0.62

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2231.36   (req: < 5)

Gene RIFs: 684   (req: <= 3)

Antibodies: 993   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2231.36   (req: >= 5)

Gene RIFs: 684   (req: > 3)

Antibodies: 993   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0