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Tbio
IL32
Interleukin-32

Protein Summary
Description
Cytokine that may play a role in innate and adaptive immune responses. It induces various cytokines such as TNFA/TNF-alpha and IL8. It activates typical cytokine signal pathways of NF-kappa-B and p38 MAPK. This gene encodes a member of the cytokine family. The protein contains a tyrosine sulfation site, 3 potential N-myristoylation sites, multiple putative phosphorylation sites, and an RGD cell-attachment sequence. Expression of this protein is increased after the activation of T-cells by mitogens or the activation of NK cells by IL-2. This protein induces the production of TNFalpha from macrophage cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000008180
  • ENSP00000008180
  • ENSG00000008517
  • ENST00000325568
  • ENSP00000324742
  • ENST00000382213
  • ENSP00000371648
  • ENST00000396887
  • ENSP00000380096
  • ENST00000396890
  • ENSP00000380099
  • ENST00000440815
  • ENSP00000405063
  • ENST00000444393
  • ENSP00000411958
  • ENST00000525643
  • ENSP00000432218
  • ENST00000526464
  • ENSP00000450364
  • ENST00000528163
  • ENSP00000432850
  • ENST00000529550
  • ENSP00000437020
  • ENST00000530538
  • ENSP00000436929
  • ENST00000530890
  • ENSP00000433747
  • ENST00000531965
  • ENSP00000433177
  • ENST00000533097
  • ENSP00000432917
  • ENST00000534507
  • ENSP00000431775
  • ENST00000548246
  • ENSP00000447979
  • ENST00000548476
  • ENSP00000449483
  • ENST00000548652
  • ENSP00000446624
  • ENST00000549213
  • ENSP00000447812
  • ENST00000551122
  • ENSP00000447496
  • ENST00000552356
  • ENSP00000446978
  • ENST00000552664
  • ENSP00000448683

Symbol
  • NK4
  • TAIF
  • NK4
  • TAIF
  • TAIFa
  • TAIFb
  • TAIFc
  • TAIFd
  • IL-32beta
  • IL-32alpha
  • IL-32delta
  • IL-32gamma
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.83
small molecule perturbation
0.59
gene perturbation
0.57
PubMedID
0.53
tissue sample
0.51


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 431.97   (req: < 5)
Gene RIFs: 152   (req: <= 3)
Antibodies: 546   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 431.97   (req: >= 5)
Gene RIFs: 152   (req: > 3)
Antibodies: 546   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0