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Tbio
IL31RA
Interleukin-31 receptor subunit alpha

Protein Summary
Description
Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5 (PubMed:11877449, PubMed:14504285, PubMed:15627637, PubMed:15194700). May function in skin immunity (PubMed:15184896). Mediates IL31-induced itch, probably in a manner dependent on cation channels TRPA1 and TRPV1 (By similarity). Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro (By similarity). The protein encoded by this gene belongs to the type I cytokine receptor family. This receptor, with homology to gp130, is expressed on monocytes, and is involved in IL-31 signaling via activation of STAT-3 and STAT-5. It functions either as a monomer, or as part of a receptor complex with oncostatin M receptor (OSMR). Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297015
  • ENSP00000297015
  • ENSG00000164509
  • ENST00000354961
  • ENSP00000347047
  • ENST00000359040
  • ENSP00000351935
  • ENST00000396834
  • ENSP00000380046
  • ENST00000396836
  • ENSP00000380048
  • ENST00000447346
  • ENSP00000415900
  • ENST00000490985
  • ENSP00000427533

Symbol
  • CRL3
  • GPL
  • CRL
  • GPL
  • CRL3
  • GLMR
  • GLM-R
  • PLCA2
  • hGLM-R
  • IL-31RA
  • PRO21384
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.83
tissue
0.64
molecular function
0.6
gene perturbation
0.59
cell type or tissue
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 197.74   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 254   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 197.74   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 254   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (49)
CALHM4
Tdark
Family:  IC
Novelty:  2.79788039
p_int:  0.999989788
p_ni:  0.000010206
p_wrong:  6e-9
Data Source:  BioPlex
LYG2
Tbio
Family:  Enzyme
Novelty:  0.12091256
p_int:  0.999984153
p_ni:  0.000015847
Data Source:  BioPlex
CRYBG1
Tbio
Novelty:  0.05471025
p_int:  0.999976892
p_ni:  0.000023108
Score:  0.177
Data Source:  BioPlex,STRINGDB
HEPHL1
Tbio
Novelty:  0.44678065
p_int:  0.999965852
p_ni:  0.000034148
Data Source:  BioPlex
PLCD1
Tchem
Family:  Enzyme
Novelty:  0.00742197
p_int:  0.999964203
p_ni:  0.000035797
Data Source:  BioPlex
VSIG8
Tdark
Novelty:  1.16023405
p_int:  0.999949358
p_ni:  0.000050642
Data Source:  BioPlex
DSG4
Tbio
Novelty:  0.01599371
p_int:  0.999945876
p_ni:  0.000054124
Data Source:  BioPlex
DUSP14
Tbio
Family:  Enzyme
Novelty:  0.04013065
p_int:  0.999323028
p_ni:  0.000676965
p_wrong:  7e-9
Data Source:  BioPlex
LRRC15
Tbio
Novelty:  0.03701624
p_int:  0.999181863
p_ni:  0.000818137
Data Source:  BioPlex
PLBD1
Tdark
Family:  Enzyme
Novelty:  0.27639575
p_int:  0.998297289
p_ni:  0.001660125
p_wrong:  0.000042585
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
IL-6-type cytokine receptor ligand interactions
Reactome
Immune System
Reactome
Interleukin-6 family signaling
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
IL-6-type cytokine receptor ligand interactions
Immune System
Interleukin-6 family signaling
Signaling by Interleukins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
1
1
69.9
interleukin 6 receptor subunit beta measurement
1
1
1
67.2
mean corpuscular volume
1
1
1
29
lymphocyte count
1
1
1
15.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
69.9
interleukin 6 receptor subunit beta measurement
1
67.2
mean corpuscular volume
1
29
lymphocyte count
1
15.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interleukin 31 receptor A
VGNC:4045
471545
Macaque
interleukin 31 receptor A
709719
Mouse
MGI:2180511
218624
Rat
RGD:1586478
688622
Dog
interleukin 31 receptor A
VGNC:41981
487212
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interleukin 31 receptor A
Macaque
interleukin 31 receptor A
Mouse
Rat
Dog
interleukin 31 receptor A
Publication Statistics
PubMed Score 197.74
PubMed score by year
PubTator Score 384.66
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title