You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
IL3
Interleukin-3

Protein Summary
Description
Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes. The protein encoded by this gene is a potent growth promoting cytokine. This cytokine is capable of supporting the proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as cell growth, differentiation and apoptosis. This cytokine has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296870
  • ENSP00000296870
  • ENSG00000164399

Symbol
  • IL-3
  • MCGF
  • MULTI-CSF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue
0.82
biological term
0.8
biological process
0.78
disease
0.67
chemical
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3884.51   (req: < 5)
Gene RIFs: 82   (req: <= 3)
Antibodies: 722   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3884.51   (req: >= 5)
Gene RIFs: 82   (req: > 3)
Antibodies: 722   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (300)
IL3RA
Tclin
Novelty:  0.00216495
Score:  0.997
Data Source:  Reactome,STRINGDB
CSF2
Tbio
Novelty:  0.00010437
Score:  0.995
Data Source:  STRINGDB
IL2
Tchem
Novelty:  0.00003129
Score:  0.989
Data Source:  STRINGDB
IL5
Tclin
Novelty:  0.0001684
Score:  0.987
Data Source:  STRINGDB
STAT5B
Tchem
Family:  TF
Novelty:  0.00074178
Score:  0.984
Data Source:  Reactome,STRINGDB
STAT5A
Tchem
Family:  TF
Novelty:  0.00074026
Score:  0.983
Data Source:  Reactome,STRINGDB
CSF2RB
Tclin
Novelty:  0.02093804
Score:  0.978
Data Source:  Reactome,STRINGDB
JAK2
Tclin
Family:  Kinase
Novelty:  0.00022894
Score:  0.966
Data Source:  Reactome,STRINGDB
HRAS
Tchem
Family:  Enzyme
Novelty:  0.00008069
Score:  0.963
Data Source:  STRINGDB
IL5RA
Tclin
Novelty:  0.01418963
Score:  0.962
Data Source:  STRINGDB
Nearest Tclin Targets (17)
Explore Nearest Tclin Targets
Pathways (50)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
FLT3 Signaling
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
FLT3 Signaling
Gene expression (Transcription)
Generic Transcription Pathway
Immune System
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (17)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
2
2
2
89.7
eosinophil count
2
2
2
89.1
eosinophil percentage of granulocytes
1
1
1
48.3
sum of eosinophil and basophil counts
1
1
1
48.3
neutrophil percentage of granulocytes
1
1
1
46.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
2
89.7
eosinophil count
2
89.1
eosinophil percentage of granulocytes
1
48.3
sum of eosinophil and basophil counts
1
48.3
neutrophil percentage of granulocytes
1
46.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interleukin 3
VGNC:4044
471626
Macaque
interleukin 3
706946
Dog
interleukin 3
VGNC:53502
481497
Cow
interleukin 3 (colony-stimulating factor, multiple)
280823
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interleukin 3
Macaque
interleukin 3
Dog
interleukin 3
Cow
interleukin 3 (colony-stimulating factor, multiple)
Publication Statistics
PubMed Score 3884.51
PubMed score by year
PubTator Score 1945.94
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title