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Tclin
IL2RG
Cytokine receptor common subunit gamma

Protein Summary
Description
Common subunit for the receptors for a variety of interleukins. The protein encoded by this gene is an important signaling component of many interleukin receptors, including those of interleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain. Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID), as well as X-linked combined immunodeficiency (XCID), a less severe immunodeficiency disorder. [provided by RefSeq, Mar 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374202
  • ENSP00000363318
  • ENSG00000147168
  • ENST00000456850
  • ENSP00000388967

Symbol
  • P64
  • CIDX
  • IMD4
  • CD132
  • SCIDX
  • IL-2RG
  • SCIDX1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.98
disease perturbation
0.97
phenotype
0.7
biological term
0.66
cellular component
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 942.75   (req: < 5)
Gene RIFs: 60   (req: <= 3)
Antibodies: 564   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 942.75   (req: >= 5)
Gene RIFs: 60   (req: > 3)
Antibodies: 564   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (283)
REEP6
Tbio
Novelty:  0.10645981
p_int:  0.999339747
p_ni:  0.000463826
p_wrong:  0.000196427
Score:  0.295
Data Source:  BioPlex,STRINGDB
CD320
Tbio
Novelty:  0.01978884
p_int:  0.928431385
p_ni:  0.071564676
p_wrong:  0.000003939
Score:  0.189
Data Source:  BioPlex,STRINGDB
PTPRD
Tbio
Family:  Enzyme
Novelty:  0.01059407
p_int:  0.900583591
p_ni:  0.030767232
p_wrong:  0.068649178
Score:  0.276
Data Source:  BioPlex,STRINGDB
FLVCR1
Tbio
Novelty:  0.02110276
p_int:  0.86536942
p_ni:  0.134630579
p_wrong:  1e-9
Score:  0.211
Data Source:  BioPlex,STRINGDB
IL2RB
Tclin
Novelty:  0.0050905
Score:  0.998
Data Source:  Reactome,STRINGDB
IL2
Tchem
Novelty:  0.00003129
Score:  0.997
Data Source:  Reactome,STRINGDB
IL4
Tbio
Novelty:  0.00005852
Score:  0.996
Data Source:  Reactome,STRINGDB
IL15
Tbio
Novelty:  0.00049351
Score:  0.996
Data Source:  Reactome,STRINGDB
IL4R
Tclin
Novelty:  0.00359183
Score:  0.995
Data Source:  Reactome,STRINGDB
IL15RA
Tbio
Novelty:  0.03493607
Score:  0.994
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (730)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
FLT3 Signaling
Reactome
Immune System
Reactome
Interleukin receptor SHC signaling
Reactome
Interleukin-15 signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
FLT3 Signaling
Immune System
Interleukin receptor SHC signaling
Interleukin-15 signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (22)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
2
3
94.6
reticulocyte count
2
1
2
86.6
testosterone measurement
1
1
1
12
2
1
0
1
10.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
94.6
reticulocyte count
2
86.6
testosterone measurement
1
12
0
1
10.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interleukin 2 receptor subunit gamma
VGNC:12420
101059843
Macaque
interleukin 2 receptor subunit gamma
641338
Mouse
MGI:96551
16186
Rat
RGD:621466
140924
Dog
interleukin 2 receptor subunit gamma
VGNC:41979
403851
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interleukin 2 receptor subunit gamma
Macaque
interleukin 2 receptor subunit gamma
Mouse
Rat
Dog
interleukin 2 receptor subunit gamma
Publication Statistics
PubMed Score 942.75
PubMed score by year
PubTator Score 391.36
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title