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Tclin
IL2RB
Interleukin-2 receptor subunit beta

Protein Summary
Description
Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein. The use of alternative promoters results in multiple transcript variants encoding the same protein. The protein is primarily expressed in the hematopoietic system. The use by some variants o ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216223
  • ENSP00000216223
  • ENSG00000100385

Symbol
  • IL15RB
  • CD122
  • IL15RB
  • P70-75
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.92
disease
0.74
phenotype
0.7
cell type or tissue
0.66
tissue sample
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 144.62   (req: < 5)
Gene RIFs: 58   (req: <= 3)
Antibodies: 833   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 144.62   (req: >= 5)
Gene RIFs: 58   (req: > 3)
Antibodies: 833   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (334)
IL2RG
Tclin
Novelty:  0.00108272
Score:  0.998
Data Source:  Reactome,STRINGDB
IL15
Tbio
Novelty:  0.00049351
Score:  0.998
Data Source:  Reactome,STRINGDB
IL2
Tchem
Novelty:  0.00003129
Score:  0.996
Data Source:  Reactome,STRINGDB
IL2RA
Tclin
Novelty:  0.0007607
Score:  0.996
Data Source:  Reactome,STRINGDB
IL15RA
Tbio
Novelty:  0.03493607
Score:  0.993
Data Source:  Reactome,STRINGDB
STAT5A
Tchem
Family:  TF
Novelty:  0.00074026
Score:  0.972
Data Source:  STRINGDB
CD247
Tbio
Novelty:  0.00217194
Score:  0.971
Data Source:  STRINGDB
STAT5B
Tchem
Family:  TF
Novelty:  0.00074178
Score:  0.97
Data Source:  STRINGDB
JAK3
Tclin
Family:  Kinase
Novelty:  0.00164278
Score:  0.97
Data Source:  Reactome,STRINGDB
LCK
Tclin
Family:  Kinase
Novelty:  0.00058377
Score:  0.97
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (280)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
FLT3 Signaling
Reactome
Immune System
Reactome
Interleukin receptor SHC signaling
Reactome
Interleukin-15 signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
FLT3 Signaling
Immune System
Interleukin receptor SHC signaling
Interleukin-15 signaling
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (60)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
7
11
16
99.8
hemoglobin measurement
15
8
18
99.7
mean corpuscular volume
10
5
12
98.8
HbA1c measurement
8
8
13
98.6
mean corpuscular hemoglobin
7
4
8
98.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
16
99.8
hemoglobin measurement
18
99.7
mean corpuscular volume
12
98.8
HbA1c measurement
13
98.6
mean corpuscular hemoglobin
8
98.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interleukin 2 receptor subunit beta
VGNC:6153
470203
Macaque
interleukin 2 receptor subunit beta
696331
Mouse
MGI:96550
16185
Rat
RGD:2896
25746
Dog
interleukin 2 receptor subunit beta
VGNC:41978
403439
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interleukin 2 receptor subunit beta
Macaque
interleukin 2 receptor subunit beta
Mouse
Rat
Dog
interleukin 2 receptor subunit beta
Publication Statistics
PubMed Score 144.62
PubMed score by year
PubTator Score 1204.49
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title