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Tbio
IL27
Interleukin-27 subunit alpha

Protein Summary
Description
Associates with EBI3 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR which appears to be required but not sufficient for IL-27-mediated signal transduction. IL-27 potentiate the early phase of TH1 response and suppress TH2 and TH17 differentiation. It induces the differentiation of TH1 cells via two distinct ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356897
  • ENSP00000349365
  • ENSG00000197272

Symbol
  • IL27A
  • IL30
  • p28
  • IL30
  • IL-27
  • IL27A
  • IL-27A
  • IL27p28
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.9
biological process
0.63
cell type or tissue
0.54
transcription factor
0.52
tissue
0.49


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.61   (req: < 5)
Gene RIFs: 217   (req: <= 3)
Antibodies: 570   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.61   (req: >= 5)
Gene RIFs: 217   (req: > 3)
Antibodies: 570   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (38)
IL27RA
Tbio
Novelty:  0.01348051
Score:  0.984
Data Source:  Reactome,STRINGDB
EBI3
Tbio
Novelty:  0.09651194
Score:  0.984
Data Source:  Reactome,STRINGDB
IL6ST
Tclin
Novelty:  0.01026472
Score:  0.957
Data Source:  Reactome,STRINGDB
STAT1
Tchem
Family:  TF
Novelty:  0.0003383
Score:  0.951
Data Source:  Reactome,STRINGDB
STAT3
Tchem
Family:  TF
Novelty:  0.00011808
Score:  0.941
Data Source:  Reactome,STRINGDB
CRLF1
Tbio
Novelty:  0.02127014
Score:  0.939
Data Source:  Reactome,STRINGDB
STAT4
Tchem
Family:  TF
Novelty:  0.00251747
Score:  0.925
Data Source:  STRINGDB
JAK1
Tclin
Family:  Kinase
Novelty:  0.00093625
Score:  0.925
Data Source:  Reactome,STRINGDB
STAT5A
Tchem
Family:  TF
Novelty:  0.00074026
Score:  0.924
Data Source:  STRINGDB
JAK2
Tclin
Family:  Kinase
Novelty:  0.00022894
Score:  0.92
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-12 family signaling
Reactome
Interleukin-27 signaling
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-12 family signaling
Interleukin-27 signaling
Signaling by Interleukins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (30)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
3
3
97
mean platelet volume
3
2
3
95.2
platelet crit
2
2
3
91.9
intelligence
3
15
8
6.4
91.1
2
2
0
1.1
86.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
3
97
mean platelet volume
3
95.2
platelet crit
3
91.9
intelligence
8
6.4
91.1
0
1.1
86.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interleukin 27
VGNC:13718
737725
Mouse
MGI:2384409
246779
Rat
RGD:1561420
365368
Dog
interleukin 27
VGNC:41976
607880
Horse
interleukin 27
VGNC:19024
100066317
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interleukin 27
Mouse
Rat
Dog
interleukin 27
Horse
interleukin 27
Publication Statistics
PubMed Score 76.61
PubMed score by year
PubTator Score 332.59
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title