Tbio IL24 Interleukin-24

Protein Summary

Description

Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation. This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q13007
• Q2YHE5
• Q53XZ7
• Q5YLN8
• Q96DB0
• Q96KG4
• IL-24

Gene Name

• IL24

Ensembl ID

• ENST00000294984
• ENSP00000294984
• ENSG00000162892
• ENST00000367093
• ENSP00000356060
• ENST00000391929
• ENSP00000375795
• ENST00000611909
• ENSP00000484900

Symbol

• MDA7
• ST16
• C49A
• FISP
• MDA7
• MOB5
• ST16
• IL10B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.94
gene perturbation	0.9
biological term	0.85
protein domain	0.73
PubMedID	0.72

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 698.85   (req: < 5)

Gene RIFs: 147   (req: <= 3)

Antibodies: 338   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 698.85   (req: >= 5)

Gene RIFs: 147   (req: > 3)

Antibodies: 338   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0