Tclin IL23A Interleukin-23 subunit alpha

Protein Summary

Description

Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9NPF7
• Q6NZ80
• Q6NZ82
• Q9H2A5
• IL-23 subunit alpha

Gene Name

• IL23A

Ensembl ID

• ENST00000228534
• ENSP00000228534
• ENSG00000110944

Symbol

• SGRF
• P19
• SGRF
• IL-23
• IL-23A
• IL23P19

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
biological term	0.97
gene perturbation	0.84
virus perturbation	0.76
transcription factor	0.7

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Cytokine / Interleukin Superfamily / Interleukin-23 Subunit Alpha

DTO Classes

Protein / Signaling / Cytokine / Interleukin Superfamily / Interleukin-23 Subunit Alpha

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 229.43   (req: < 5)

Gene RIFs: 320   (req: <= 3)

Antibodies: 601   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 229.43   (req: >= 5)

Gene RIFs: 320   (req: > 3)

Antibodies: 601   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 38

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4