IL20RA
Interleukin-20 receptor subunit alpha
Protein Summary
The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26. This gene encodes a member of the type II cytokine receptor family. The encoded protein is a subunit of the receptor for interleukin 20, a cytokine that may be involved in epidermal function. The interleukin 20 receptor is a heterodimeric complex consisting of the encoded protein and interleukin 20 receptor beta. This gene and interleukin 20 receptor beta are highly expressed in skin, and are upregulated in psoriasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
- ENST00000316649
- ENSP00000314976
- ENSG00000016402
- ENST00000367748
- ENSP00000356722
- ENST00000541547
- ENSP00000437843
- CRF2-8
- IL-20R1
- IL-20RA
- IL-20R-alpha
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
PubMedID | 0.63 | ||
trait | 0.61 | ||
protein domain | 0.58 | ||
gene perturbation | 0.56 | ||
histone modification site profile | 0.5 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 37.62 (req: < 5)
Gene RIFs: 10 (req: <= 3)
Antibodies: 333 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 37.62 (req: >= 5)
Gene RIFs: 10 (req: > 3)
Antibodies: 333 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (114)
TNIK
Family: Kinase
Novelty: 0.02681864
p_int: 0.999745016
p_ni: 0.000242022
p_wrong: 0.000012962
Score: 0.175
Data Source: BioPlex,STRINGDB
LAPTM4B
Novelty: 0.01162533
p_int: 0.998902121
p_ni: 0.000914146
p_wrong: 0.000183733
Data Source: BioPlex
DIRAS1
Family: Enzyme
Novelty: 0.13332903
p_int: 0.997668921
p_ni: 0.00214713
p_wrong: 0.000183949
Data Source: BioPlex
STAT3
Family: TF
Novelty: 0.00011808
p_int: 0.996430977
p_ni: 0.003569023
Score: 0.955
Data Source: BioPlex,Reactome,STRINGDB
PIK3CA
Family: Kinase
Novelty: 0.00044273
p_int: 0.995638023
p_ni: 0.004361975
p_wrong: 2e-9
Data Source: BioPlex
CYB5R1
Family: Enzyme
Novelty: 0.07714146
p_int: 0.994259009
p_ni: 0.005740991
Data Source: BioPlex
ROCK1
Family: Kinase
Novelty: 0.00156045
p_int: 0.992847769
p_ni: 0.00034861
p_wrong: 0.00680362
Score: 0.17
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (9)
Upstream (5)
Downstream (4)
1 – 5 of 5
Pathways (9)
Reactome (4)
KEGG (3)
PathwayCommons (1)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Immune System | ||||
Reactome | Interleukin-20 family signaling | ||||
Reactome | Signaling by Interleukins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cytokine Signaling in Immune system | ||||
Immune System | ||||
Interleukin-20 family signaling | ||||
Signaling by Interleukins | ||||
Viral Interactions (0)
Gene Ontology Terms (6)
Functions (1)
Components (2)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
7 | 6 | 3 | 1.1 | 95.9 | |||||
3 | 2 | 0 | 1.1 | 81.7 | |||||
coffee consumption measurement | 1 | 1 | 1 | 63.7 | |||||
tea consumption measurement | 2 | 1 | 2 | 63.7 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
3 | 1.1 | 95.9 | |||||
0 | 1.1 | 81.7 | |||||
coffee consumption measurement | 1 | 63.7 | |||||
tea consumption measurement | 2 | 63.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | interleukin 20 receptor subunit alpha | VGNC:3242 | 463026 | |||||
Macaque | interleukin 20 receptor subunit alpha | 704890 | ||||||
Mouse | MGI:3605069 | 237313 | ||||||
Rat | RGD:1307335 | 308716 | ||||||
Dog | interleukin 20 receptor subunit alpha | VGNC:41965 | 484002 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | interleukin 20 receptor subunit alpha | |||||
Macaque | interleukin 20 receptor subunit alpha | |||||
Mouse | ||||||
Rat | ||||||
Dog | interleukin 20 receptor subunit alpha | |||||
Publication Statistics
PubMed Score 37.62
PubMed score by year
PubTator Score 18.40
PubTator score by year
Related Publications
Text Mined References (27)
GeneRif Annotations (10)
Items per page:
0 of 0
PMID | Year | Title |
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