Protein Summary
Proinflammatory and angiogenic cytokine that may be involved in epidermal function and psoriasis. Angiogenic and proliferative activities are antagonized by IL10. May act through STAT3. The protein encoded by this gene is a cytokine structurally related to interleukin 10 (IL10). This cytokine has been shown to transduce its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis. [provided by RefSeq, Jul 2008]
- ENST00000367096
- ENSP00000356063
- ENSG00000162891
- ENST00000367098
- ENSP00000356065
- ENST00000391930
- ENSP00000375796
- ZCYTO10
- IL-20
- IL10D
- ZCYTO10
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.73 | ||
biological process | 0.67 | ||
biological term | 0.64 | ||
cell line | 0.6 | ||
pathway | 0.45 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 0.23 (req: < 5)
Gene RIFs: 57 (req: <= 3)
Antibodies: 421 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 0.23 (req: >= 5)
Gene RIFs: 57 (req: > 3)
Antibodies: 421 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (64)
EMB
Novelty: 0.00135577
p_int: 0.999459694
p_ni: 0.000536659
p_wrong: 0.000003646
Data Source: BioPlex
PPM1A
Family: Enzyme
Novelty: 0.01464968
p_int: 0.998006335
p_ni: 0.001924359
p_wrong: 0.000069306
Data Source: BioPlex
HRAS
Family: Enzyme
Novelty: 0.00008069
p_int: 0.957540123
p_ni: 0.041782606
p_wrong: 0.00067727
Data Source: BioPlex
GFER
Family: Enzyme
Novelty: 0.00338563
p_int: 0.944074155
p_ni: 0.055924884
p_wrong: 9.62e-7
Data Source: BioPlex
RTN4RL2
Novelty: 0.05919593
p_int: 0.881585663
p_ni: 0.002716177
p_wrong: 0.11569816
Data Source: BioPlex
MICA
Novelty: 0.03965901
p_int: 0.821711824
p_ni: 0.178277334
p_wrong: 0.000010841
Data Source: BioPlex
CADM4
Novelty: 0.05034541
p_int: 0.786085162
p_ni: 0.113812132
p_wrong: 0.100102706
Data Source: BioPlex
GNG5
Novelty: 0.1525101
p_int: 0.752823372
p_ni: 0.247142417
p_wrong: 0.000034211
Data Source: BioPlex
Nearest Tclin Targets (17)
Downstream (17)
1 – 5 of 17
Pathways (7)
Reactome (4)
KEGG (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Immune System | ||||
Reactome | Interleukin-20 family signaling | ||||
Reactome | Signaling by Interleukins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cytokine Signaling in Immune system | ||||
Immune System | ||||
Interleukin-20 family signaling | ||||
Signaling by Interleukins | ||||
Viral Interactions (0)
Gene Ontology Terms (11)
Functions (3)
Components (2)
Processes (6)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations (null)
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
Oral ulcer | 1 | 4 | 0 | 1.1 | 98.7 | ||||
6 | 2 | 1 | 1.3 | 87.3 | |||||
2 | 2 | 0 | 1.4 | 81.6 | |||||
4 | 3 | 0 | 1.2 | 72.3 | |||||
eosinophil count | 2 | 1 | 2 | 55.2 | |||||
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
Oral ulcer | 0 | 1.1 | 98.7 | ||||
1 | 1.3 | 87.3 | |||||
0 | 1.4 | 81.6 | |||||
0 | 1.2 | 72.3 | |||||
eosinophil count | 2 | 55.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | interleukin 20 | VGNC:1268 | 744201 | |||||
Macaque | interleukin 20 | 694689 | ||||||
Mouse | MGI:1890473 | 58181 | ||||||
Rat | RGD:1583578 | 681112 | ||||||
Dog | interleukin 20 | VGNC:41964 | 609203 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | interleukin 20 | |||||
Macaque | interleukin 20 | |||||
Mouse | ||||||
Rat | ||||||
Dog | interleukin 20 | |||||
Publication Statistics
PubMed Score 0.23
PubMed score by year
PubTator Score 86.08
PubTator score by year
Related Publications
Text Mined References (69)
GeneRif Annotations (57)
Items per page:
0 of 0
PMID | Year | Title |
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