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Tbio
IL20
Interleukin-20

Protein Summary
Description
Proinflammatory and angiogenic cytokine that may be involved in epidermal function and psoriasis. Angiogenic and proliferative activities are antagonized by IL10. May act through STAT3. The protein encoded by this gene is a cytokine structurally related to interleukin 10 (IL10). This cytokine has been shown to transduce its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367096
  • ENSP00000356063
  • ENSG00000162891
  • ENST00000367098
  • ENSP00000356065
  • ENST00000391930
  • ENSP00000375796

Symbol
  • ZCYTO10
  • IL-20
  • IL10D
  • ZCYTO10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
biological process
0.67
biological term
0.64
cell line
0.6
pathway
0.45


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.23   (req: < 5)
Gene RIFs: 57   (req: <= 3)
Antibodies: 421   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.23   (req: >= 5)
Gene RIFs: 57   (req: > 3)
Antibodies: 421   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (64)
EMB
Tbio
Novelty:  0.00135577
p_int:  0.999459694
p_ni:  0.000536659
p_wrong:  0.000003646
Data Source:  BioPlex
PPM1A
Tchem
Family:  Enzyme
Novelty:  0.01464968
p_int:  0.998006335
p_ni:  0.001924359
p_wrong:  0.000069306
Data Source:  BioPlex
LRP2
Tbio
Novelty:  0.00143258
p_int:  0.970296414
p_ni:  0.029703586
Data Source:  BioPlex
HRAS
Tchem
Family:  Enzyme
Novelty:  0.00008069
p_int:  0.957540123
p_ni:  0.041782606
p_wrong:  0.00067727
Data Source:  BioPlex
GFER
Tchem
Family:  Enzyme
Novelty:  0.00338563
p_int:  0.944074155
p_ni:  0.055924884
p_wrong:  9.62e-7
Data Source:  BioPlex
RTN4RL2
Tbio
Novelty:  0.05919593
p_int:  0.881585663
p_ni:  0.002716177
p_wrong:  0.11569816
Data Source:  BioPlex
MICA
Tbio
Novelty:  0.03965901
p_int:  0.821711824
p_ni:  0.178277334
p_wrong:  0.000010841
Data Source:  BioPlex
CADM4
Tbio
Novelty:  0.05034541
p_int:  0.786085162
p_ni:  0.113812132
p_wrong:  0.100102706
Data Source:  BioPlex
GNG5
Tbio
Novelty:  0.1525101
p_int:  0.752823372
p_ni:  0.247142417
p_wrong:  0.000034211
Data Source:  BioPlex
IL20RA
Tbio
Novelty:  0.02416816
Score:  0.994
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets (17)
Explore Nearest Tclin Targets
Pathways (7)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-20 family signaling
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-20 family signaling
Signaling by Interleukins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Oral ulcer
1
4
0
1.1
98.7
6
2
1
1.3
87.3
2
2
0
1.4
81.6
4
3
0
1.2
72.3
eosinophil count
2
1
2
55.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Oral ulcer
0
1.1
98.7
1
1.3
87.3
0
1.4
81.6
0
1.2
72.3
eosinophil count
2
55.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interleukin 20
VGNC:1268
744201
Macaque
interleukin 20
694689
Mouse
MGI:1890473
58181
Rat
RGD:1583578
681112
Dog
interleukin 20
VGNC:41964
609203
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interleukin 20
Macaque
interleukin 20
Mouse
Rat
Dog
interleukin 20
Publication Statistics
PubMed Score 0.23
PubMed score by year
PubTator Score 86.08
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title