Protein Summary
Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells. The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008]
- ENST00000226730
- ENSP00000226730
- ENSG00000109471
- IL-2
- TCGF
- lymphokine
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
biological term | 1 | ||
chemical | 1 | ||
disease | 0.87 | ||
molecular function | 0.79 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 31863.38 (req: < 5)
Gene RIFs: 488 (req: <= 3)
Antibodies: 1832 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 31863.38 (req: >= 5)
Gene RIFs: 488 (req: > 3)
Antibodies: 1832 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 45
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 16
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (16)
Protein-Protein Interactions (762)
IL17A
Novelty: 0.00011583
p_int: 0.999999999
p_ni: 1e-9
Score: 0.982
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (20)
Upstream (3)
Downstream (17)
1 – 3 of 3
Pathways (71)
Reactome (18)
KEGG (19)
PathwayCommons (15)
WikiPathways (19)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | FLT3 Signaling | ||||
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Reactome | Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cytokine Signaling in Immune system | ||||
FLT3 Signaling | ||||
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
Immune System | ||||
Viral Interactions (0)
Gene Ontology Terms (48)
Functions (8)
Components (3)
Processes (37)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | MGI | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (19)
Items per page:
1 – 5 of 19
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
6 | 6 | 3 | 1.1 | 92.8 | |||||
4 | 4 | 0 | 1.1 | 92.7 | |||||
6 | 4 | 0 | 1.1 | 92.6 | |||||
childhood onset asthma | 2 | 2 | 0 | 1.1 | 85.3 | ||||
eosinophil count | 1 | 1 | 1 | 82.6 | |||||
Items per page:
1 – 5 of 19
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
3 | 1.1 | 92.8 | |||||
0 | 1.1 | 92.7 | |||||
0 | 1.1 | 92.6 | |||||
childhood onset asthma | 0 | 1.1 | 85.3 | ||||
eosinophil count | 1 | 82.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | interleukin 2 | VGNC:617 | 461472 | |||||
Macaque | interleukin 2 | 708017 | ||||||
Mouse | MGI:96548 | 16183 | ||||||
Rat | RGD:620047 | 116562 | ||||||
Dog | interleukin 2 | VGNC:41963 | 403989 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | interleukin 2 | |||||
Macaque | interleukin 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | interleukin 2 | |||||
Publication Statistics
PubMed Score 31863.38
PubMed score by year
PubTator Score 17629.10
PubTator score by year
Related Publications
Text Mined References (712)
GeneRif Annotations (488)
Items per page:
0 of 0
PMID | Year | Title |
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