Tchem IL1RN Interleukin-1 receptor antagonist protein

Protein Summary

Description

Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure. The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jan 2016]

Uniprot Accession IDs

• P18510
• A8K4G1
• Q14628
• Q53SC2
• Q7RTZ4
• Q96GD6
• Q9UPC0
• IL-1RN

Gene Name

• IL1RN

Ensembl ID

• ENST00000259206
• ENSP00000259206
• ENSG00000136689
• ENST00000354115
• ENSP00000329072
• ENST00000361779
• ENSP00000354816
• ENST00000409052
• ENSP00000387210
• ENST00000409930
• ENSP00000387173

Symbol

• IL1F3
• IL1RA
• DIRA
• IRAP
• IL1F3
• IL1RA
• MVCD4
• IL-1RN
• IL-1ra
• IL-1ra3
• ICIL-1RA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
biological term	1
disease	0.93
gene perturbation	0.8
transcription factor perturbation	0.8

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1658.67   (req: < 5)

Gene RIFs: 560   (req: <= 3)

Antibodies: 806   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1658.67   (req: >= 5)

Gene RIFs: 560   (req: > 3)

Antibodies: 806   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1