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Tclin
IL1RAP
Interleukin-1 receptor accessory protein

Protein Summary
Description
Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system. Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity). May play a role in IL1B-mediated costimulation of IFNG production fr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000072516
  • ENSP00000072516
  • ENSG00000196083
  • ENST00000317757
  • ENSP00000314807
  • ENST00000342550
  • ENSP00000345829
  • ENST00000412504
  • ENSP00000412053
  • ENST00000413869
  • ENSP00000416296
  • ENST00000422485
  • ENSP00000409352
  • ENST00000422940
  • ENSP00000387371
  • ENST00000439062
  • ENSP00000401132
  • ENST00000443369
  • ENSP00000408893
  • ENST00000447382
  • ENSP00000390541

Symbol
  • C3orf13
  • IL1R3
  • IL1R3
  • C3orf13
  • IL-1RAcP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.98
trait
0.93
transcription factor perturbation
0.88
protein domain
0.85
gene perturbation
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.11   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 363   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.11   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 363   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1