Tbio IL1R2 Interleukin-1 receptor type 2

Protein Summary

Description

Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage. [provided by RefSeq, May 2012]

Uniprot Accession IDs

• P27930
• D3DVJ5
• Q6LCE6
• Q9UE68
• IL-1R-2

Gene Name

• IL1R2

Ensembl ID

• ENST00000332549
• ENSP00000330959
• ENSG00000115590
• ENST00000393414
• ENSP00000377066
• ENST00000441002
• ENSP00000414611

Symbol

• IL1RB
• IL1RB
• CD121b
• IL1R2c
• CDw121b
• IL-1R-2
• IL-1RT2
• IL-1RT-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.96
protein domain	0.92
disease	0.79
small molecule perturbation	0.71
transcription factor perturbation	0.68

Protein Classes

PANTHER Classes

Protein / Receptor / Cytokine Receptor / Type I Cytokine Receptor / Interleukin-1 Receptor Type 2

DTO Classes

Protein / Receptor / Cytokine Receptor / Type I Cytokine Receptor / Interleukin-1 Receptor Type 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.12   (req: < 5)

Gene RIFs: 54   (req: <= 3)

Antibodies: 566   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.12   (req: >= 5)

Gene RIFs: 54   (req: > 3)

Antibodies: 566   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (107)

Explore Interacting Targets

1 – 10 of 107

• See Interactions on String-DB

EXOC6B

Tbio

Novelty:  0.11301293

p_int:  0.999999983

p_ni:  1.7e-8

Score:  0.551

Data Source:  BioPlex,STRINGDB

CCDC51

Tdark

Novelty:  1.19203634

p_int:  0.999998727

p_ni:  0.000001273

Data Source:  BioPlex

EXOC6

Tbio

Novelty:  0.01886811

p_int:  0.999994882

p_ni:  0.000005116

p_wrong:  1e-9

Score:  0.594

Data Source:  BioPlex,STRINGDB

NUDT16

Tbio

Novelty:  0.06032864

p_int:  0.999988601

p_ni:  0.000011399

Score:  0.188

Data Source:  BioPlex,STRINGDB

EXOC5

Tbio

Novelty:  0.02200205

p_int:  0.999972316

p_ni:  0.000027684

Score:  0.544

Data Source:  BioPlex,STRINGDB

EXOC7

Tbio

Novelty:  0.00852508

p_int:  0.999972277

p_ni:  0.000027723

Score:  0.452

Data Source:  BioPlex,STRINGDB

EXOC1

Tbio

Novelty:  0.01073858

p_int:  0.999918156

p_ni:  0.000081844

Score:  0.194

Data Source:  BioPlex,STRINGDB

TRMU

Tbio

Family:  Enzyme

Novelty:  0.01615197

p_int:  0.999910981

p_ni:  0.000037765

p_wrong:  0.000051254

Data Source:  BioPlex

EXOC2

Tbio

Novelty:  0.01434464

p_int:  0.999864646

p_ni:  0.000135354

Score:  0.764

Data Source:  BioPlex,STRINGDB

LONP2

Tbio

Family:  Enzyme

Novelty:  0.04499043

p_int:  0.999811161

p_ni:  0.000188831

p_wrong:  8e-9

Data Source:  BioPlex

Nearest Tclin Targets (3)

Explore Nearest Tclin Targets

Upstream (2)

Downstream (1)

1 – 2 of 2

IL1B

Tclin

Family:  Other

KEGG Distance:  1

Common Pathways:  4

1: Amoebiasis

2: Fluid shear stress and atherosclerosis

3: Hematopoietic cell lineage

4: Cytokine-cytokine receptor interaction

IL1RAP

Tclin

Family:  Other

KEGG Distance:  1

Common Pathways:  1

1: Cytokine-cytokine receptor interaction

Pathways (33)

Reactome (6)

KEGG (7)

PathwayCommons (5)

WikiPathways (15)

Cytokine Signaling in Immune system (R-HSA-1280215)

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Items per page:

5

1 – 5 of 6

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Interleukin-1 family signaling	140 targets	R-HSA-446652
Reactome	Interleukin-1 signaling	103 targets	R-HSA-9020702
Reactome	Interleukin-10 signaling	45 targets	R-HSA-6783783

Name	Explore in Pharos	Explore in Source
Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Immune System	2246 targets	R-HSA-168256
Interleukin-1 family signaling	140 targets	R-HSA-446652
Interleukin-1 signaling	103 targets	R-HSA-9020702
Interleukin-10 signaling	45 targets	R-HSA-6783783

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (14)

Functions (3)

Components (4)

Processes (7)

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Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
interleukin-1 receptor activity	Traceable Author Statement (TAS)	ProtInc
interleukin-1 binding	Inferred from Electronic Annotation (IEA)	Ensembl
interleukin-1, type II, blocking receptor activity	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations ()

No disease associations found

GWAS Traits (8)

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5

1 – 5 of 8

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
ulcerative colitis	EFO_0000729	2	2	0	1.1	62.8
C-reactive protein measurement	EFO_0004458	2	2	2		54.3
fibrinogen measurement	EFO_0004623	4	2	4		54.2
ST2 protein measurement	EFO_0010599	1	1	1		39.4
albumin:globulin ratio measurement	EFO_0005128	1	1	1		33.1

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 8

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
ulcerative colitis	EFO_0000729	0	1.1	62.8
C-reactive protein measurement	EFO_0004458	2		54.3
fibrinogen measurement	EFO_0004623	4		54.2
ST2 protein measurement	EFO_0010599	1		39.4
albumin:globulin ratio measurement	EFO_0005128	1		33.1

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Cell membrane
Complete proteome
Disulfide bond
Glycoprotein
Immunoglobulin domain
Membrane
Polymorphism
Receptor

GWAS Trait Find Similar Targets

No Header	No Header
albumin:globulin ratio measurement
asthma
C-reactive protein measurement
Crohn's disease
fibrinogen measurement
neutrophil count
ST2 protein measurement
ulcerative colitis

MGI Phenotype Find Similar Targets

No Header	No Header
hearing/vestibular/ear phenotype
homeostasis/metabolism phenotype

IDG Resources

No IDG generated resources found

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	interleukin 1 receptor type 2	VGNC:10291	470455
Macaque	interleukin 1 receptor type 2		711638
Mouse	interleukin 1 receptor, type II	MGI:96546	16178
Rat	interleukin 1 receptor type 2	RGD:621147	117022
Dog	interleukin 1 receptor type 2	VGNC:41959	481330

Species	Name	OMA	EggNOG	Inparanoid
Chimp	interleukin 1 receptor type 2
Macaque	interleukin 1 receptor type 2
Mouse	interleukin 1 receptor, type II
Rat	interleukin 1 receptor type 2
Dog	interleukin 1 receptor type 2

Publication Statistics

PubMed Score 117.12

PubMed score by year

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PubTator Score 116.26

PubTator score by year

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Related Publications

Text Mined References (111)

GeneRif Annotations (54)

Items per page:

10

0 of 0

PMID	Year	Title