Protein Summary
Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells (PubMed:10653850). The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pa ...more
- ENST00000263341
- ENSP00000263341
- ENSG00000125538
- IL1F2
- IL-1
- IL1F2
- IL1-BETA
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
biological term | 1 | ||
chemical | 1 | ||
gene perturbation | 1 | ||
small molecule perturbation | 0.93 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 33804.41 (req: < 5)
Gene RIFs: 1854 (req: <= 3)
Antibodies: 2142 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 33804.41 (req: >= 5)
Gene RIFs: 1854 (req: > 3)
Antibodies: 2142 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 95
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (2)
Active Ligands (0)
Protein-Protein Interactions (604)
Nearest Tclin Targets
Pathways (120)
Reactome (12)
KEGG (38)
PathwayCommons (19)
WikiPathways (51)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | C-type lectin receptors (CLRs) | ||||
Reactome | CLEC7A (Dectin-1) signaling | ||||
Reactome | CLEC7A/inflammasome pathway | ||||
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
C-type lectin receptors (CLRs) | ||||
CLEC7A (Dectin-1) signaling | ||||
CLEC7A/inflammasome pathway | ||||
Cytokine Signaling in Immune system | ||||
Immune System | ||||
Viral Interactions (0)
Gene Ontology Terms (101)
Functions (4)
Components (6)
Processes (91)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations (null)
GWAS Traits (17)
Items per page:
1 – 5 of 17
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean platelet volume | 2 | 2 | 3 | 94.5 | |||||
interleukin-1 beta measurement | 1 | 31 | 31 | 93.1 | |||||
neutrophil count | 1 | 2 | 2 | 68.8 | |||||
dysmenorrheic pain measurement | 2 | 2 | 2 | 67.1 | |||||
gestational age | 1 | 1 | 1 | 60.5 | |||||
Items per page:
1 – 5 of 17
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean platelet volume | 3 | 94.5 | |||||
interleukin-1 beta measurement | 31 | 93.1 | |||||
neutrophil count | 2 | 68.8 | |||||
dysmenorrheic pain measurement | 2 | 67.1 | |||||
gestational age | 1 | 60.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | interleukin 1 beta | VGNC:1940 | 450200 | |||||
Mouse | MGI:96543 | 16176 | ||||||
Rat | RGD:2891 | 24494 | ||||||
Dog | interleukin 1 beta | VGNC:41957 | 403974 | |||||
Cow | interleukin 1 beta | VGNC:52787 | 281251 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | interleukin 1 beta | |||||
Mouse | ||||||
Rat | ||||||
Dog | interleukin 1 beta | |||||
Cow | interleukin 1 beta | |||||
Publication Statistics
PubMed Score 33804.41
PubMed score by year
PubTator Score 12821.82
PubTator score by year
Related Publications
Text Mined References (2568)
GeneRif Annotations (1854)
Items per page:
0 of 0
PMID | Year | Title |
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