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Tbio
IL19
Interleukin-19

Protein Summary
Description
May play some important roles in inflammatory responses. Up-regulates IL-6 and TNF-alpha and induces apoptosis (By similarity). The protein encoded by this gene is a cytokine that belongs to the IL10 cytokine subfamily. This cytokine is found to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000270218
  • ENSP00000270218
  • ENSG00000142224
  • ENST00000340758
  • ENSP00000343000
  • ENST00000620365
  • ENSP00000482668

Symbol
  • ZMDA1
  • MDA1
  • NG.1
  • ZMDA1
  • IL-10C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
biological term
0.58
cell line
0.55
cell type or tissue
0.52
disease
0.52


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 162.57   (req: < 5)
Gene RIFs: 59   (req: <= 3)
Antibodies: 360   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 162.57   (req: >= 5)
Gene RIFs: 59   (req: > 3)
Antibodies: 360   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (93)
IL20RA
Tbio
Novelty:  0.02416816
Score:  0.985
Data Source:  Reactome,STRINGDB
IL20RB
Tbio
Novelty:  0.01747619
Score:  0.982
Data Source:  Reactome,STRINGDB
STAT3
Tchem
Family:  TF
Novelty:  0.00011808
Score:  0.945
Data Source:  Reactome,STRINGDB
JAK1
Tclin
Family:  Kinase
Novelty:  0.00093625
Score:  0.934
Data Source:  Reactome,STRINGDB
IL10RB
Tbio
Novelty:  0.00880915
Score:  0.87
Data Source:  STRINGDB
IL22RA1
Tbio
Novelty:  0.01107638
Score:  0.864
Data Source:  STRINGDB
IL10
Tbio
Novelty:  0.00004352
Score:  0.854
Data Source:  STRINGDB
IL10RA
Tbio
Novelty:  0.00506068
Score:  0.797
Data Source:  STRINGDB
IL26
Tbio
Novelty:  0.01233835
Score:  0.79
Data Source:  STRINGDB
IL22RA2
Tbio
Novelty:  0.03455127
Score:  0.768
Data Source:  STRINGDB
Nearest Tclin Targets (17)
Explore Nearest Tclin Targets
Pathways (8)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-20 family signaling
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-20 family signaling
Signaling by Interleukins
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Oral ulcer
1
5
0
1.1
99.2
6
2
1
1.3
87.3
2
2
0
1.4
81.6
4
3
0
1.2
72.3
eosinophil count
2
1
2
55.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Oral ulcer
0
1.1
99.2
1
1.3
87.3
0
1.4
81.6
0
1.2
72.3
eosinophil count
2
55.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interleukin 19
VGNC:1267
744162
Macaque
interleukin 19
694806
Mouse
MGI:1890472
329244
Rat
RGD:1583546
681145
Dog
interleukin 19
VGNC:41955
490265
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interleukin 19
Macaque
interleukin 19
Mouse
Rat
Dog
interleukin 19
Publication Statistics
PubMed Score 162.57
PubMed score by year
PubTator Score 109.79
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title